FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552912989> ?p ?o ?g. }

• W1552912989 abstract "Current advances in genomics, proteomics and other areas of molecular biology make the identification and reconstruction of novel pathways an emerging area of great interest. One such class of pathways is involved in the biogenesis of Iron-Sulfur Clusters (ISC). Our goal is the development of a new approach based on the use and combination of mathematical, theoretical and computational methods to identify the topology of a target network. In this approach, mathematical models play a central role for the evaluation of the alternative network structures that arise from literature data-mining, phylogenetic profiling, structural methods, and human curation. As a test case, we reconstruct the topology of the reaction and regulatory network for the mitochondrial ISC biogenesis pathway in S. cerevisiae. Predictions regarding how proteins act in ISC biogenesis are validated by comparison with published experimental results. For example, the predicted role of Arh1 and Yah1 and some of the interactions we predict for Grx5 both matches experimental evidence. A putative role for frataxin in directly regulating mitochondrial iron import is discarded from our analysis, which agrees with also published experimental results. Additionally, we propose a number of experiments for testing other predictions and further improve the identification of the network structure. We propose and apply an iterative in silico procedure for predictive reconstruction of the network topology of metabolic pathways. The procedure combines structural bioinformatics tools and mathematical modeling techniques that allow the reconstruction of biochemical networks. Using the Iron Sulfur cluster biogenesis in S. cerevisiae as a test case we indicate how this procedure can be used to analyze and validate the network model against experimental results. Critical evaluation of the obtained results through this procedure allows devising new wet lab experiments to confirm its predictions or provide alternative explanations for further improving the models." @default.
• W1552912989 created "2016-06-24" @default.
• W1552912989 creator A5020840486 @default.
• W1552912989 creator A5037021167 @default.
• W1552912989 date "2007-01-31" @default.
• W1552912989 modified "2023-09-24" @default.
• W1552912989 title "In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae" @default.
• W1552912989 cites W1501815954 @default.
• W1552912989 cites W1502529406 @default.
• W1552912989 cites W1534007628 @default.
• W1552912989 cites W1581582023 @default.
• W1552912989 cites W1602264642 @default.
• W1552912989 cites W16759007 @default.
• W1552912989 cites W1815692180 @default.
• W1552912989 cites W1955046737 @default.
• W1552912989 cites W1965410913 @default.
• W1552912989 cites W1972805592 @default.
• W1552912989 cites W1977013265 @default.
• W1552912989 cites W1977671794 @default.
• W1552912989 cites W1978004953 @default.
• W1552912989 cites W1981933378 @default.
• W1552912989 cites W1982194390 @default.
• W1552912989 cites W1982888190 @default.
• W1552912989 cites W1987228580 @default.
• W1552912989 cites W1987421178 @default.
• W1552912989 cites W1987675760 @default.
• W1552912989 cites W1996307860 @default.
• W1552912989 cites W1997075303 @default.
• W1552912989 cites W2000218734 @default.
• W1552912989 cites W2000352757 @default.
• W1552912989 cites W2000464453 @default.
• W1552912989 cites W2002390714 @default.
• W1552912989 cites W2003418336 @default.
• W1552912989 cites W2004790702 @default.
• W1552912989 cites W2004845050 @default.
• W1552912989 cites W2005692769 @default.
• W1552912989 cites W2006756678 @default.
• W1552912989 cites W2006837755 @default.
• W1552912989 cites W2009265061 @default.
• W1552912989 cites W2010473850 @default.
• W1552912989 cites W2013195029 @default.
• W1552912989 cites W2015642465 @default.
• W1552912989 cites W2016333765 @default.
• W1552912989 cites W2016472363 @default.
• W1552912989 cites W2018941609 @default.
• W1552912989 cites W2020257120 @default.
• W1552912989 cites W2024600894 @default.
• W1552912989 cites W2025348458 @default.
• W1552912989 cites W2031948928 @default.
• W1552912989 cites W2033746410 @default.
• W1552912989 cites W2034543587 @default.
• W1552912989 cites W2035312624 @default.
• W1552912989 cites W2035896627 @default.
• W1552912989 cites W2037036397 @default.
• W1552912989 cites W2044514479 @default.
• W1552912989 cites W2044720698 @default.
• W1552912989 cites W2047142948 @default.
• W1552912989 cites W2051182051 @default.
• W1552912989 cites W2051789226 @default.
• W1552912989 cites W2053419354 @default.
• W1552912989 cites W2056390790 @default.
• W1552912989 cites W2057042085 @default.
• W1552912989 cites W2060809301 @default.
• W1552912989 cites W2063100123 @default.
• W1552912989 cites W2063219876 @default.
• W1552912989 cites W2063597362 @default.
• W1552912989 cites W2064150730 @default.
• W1552912989 cites W2065304353 @default.
• W1552912989 cites W2067571711 @default.
• W1552912989 cites W2068803034 @default.
• W1552912989 cites W2073746011 @default.
• W1552912989 cites W2075565631 @default.
• W1552912989 cites W2075888213 @default.
• W1552912989 cites W2077393973 @default.
• W1552912989 cites W2078448486 @default.
• W1552912989 cites W2087686481 @default.
• W1552912989 cites W2088404957 @default.
• W1552912989 cites W2090154662 @default.
• W1552912989 cites W2091734240 @default.
• W1552912989 cites W2093363808 @default.
• W1552912989 cites W2096692378 @default.
• W1552912989 cites W2097520363 @default.
• W1552912989 cites W2100394721 @default.
• W1552912989 cites W2101901686 @default.
• W1552912989 cites W2102091306 @default.
• W1552912989 cites W2102144538 @default.
• W1552912989 cites W2102533986 @default.
• W1552912989 cites W2103148772 @default.
• W1552912989 cites W2104080300 @default.
• W1552912989 cites W2106913956 @default.
• W1552912989 cites W2109186010 @default.
• W1552912989 cites W2110017370 @default.
• W1552912989 cites W2115167726 @default.
• W1552912989 cites W2115953418 @default.
• W1552912989 cites W2116726967 @default.
• W1552912989 cites W2117435280 @default.
• W1552912989 cites W2117556618 @default.
• W1552912989 cites W2118459915 @default.
• W1552912989 cites W2122729932 @default.
• W1552912989 cites W2123280311 @default.

• next