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- W1552917612 abstract "Aging is accompanied by a progressive decline in immune function. Studies have shown age-related decreases in the expression and signaling efficiency of Toll-like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model, we report a highly significant increase in TLR5-induced production of IL-8 from monocytes of older individuals (P < 0.0001). Elevated IL-8 is accompanied by increased expression of TLR5, both protein and mRNA, and by increased levels of TLR5-mediated phosphorylation of MAPK p38 and ERK. We noted incomplete activation of NF-κB in response to TLR5 signaling in monocytes of elderly donors, as reflected by the absence of an associated increase in the production of TNF-α. Elevated TLR5 may provide a critical mechanism to enhance immune responsiveness in older individuals." @default.
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- W1552917612 date "2011-11-28" @default.
- W1552917612 modified "2023-10-12" @default.
- W1552917612 title "Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly" @default.
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- W1552917612 doi "https://doi.org/10.1111/j.1474-9726.2011.00759.x" @default.
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