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- W1552948637 abstract "Abstract The cytoplasmic domain (CY) of the ligand-binding α-chain of the γ-chain-associated FcRs can modulate receptor function such as phagocytosis, endocytosis, and intracellular trafficking of receptor-Ag complexes. To assess the potential role of the CY domain of human FcγRIa (CD64) α-chain in the transcriptional regulation of receptor-induced gene expression, we developed stably transfected murine macrophage cell lines expressing a full-length or a CY deletion mutant (tail-less) of human FcγRIa to analyze gene expression in response to receptor-specific cross-linking. Using the Affymetrix murine genome U74Av2 GeneChip array, we observed >100 candidate genes having ≥2-fold difference expression at 1.5 and 3 h after stimulation. Focusing on several immunologically related genes, we confirmed differential expression of M-CSF, macrophage inhibitory cytokine-1, leukocyte-specific protein 1, MIP-2, and IL-1R antagonist by RT-PCR and RNase protection assays. Analysis of mRNA stability indicated that the differential regulation of gene expression by the CY of the CD64 α-chain is at the level of gene transcription. Our results indicate that the CY of the CD64 α-chain modulates transcriptional activity induced by receptor-specific engagement in macrophages and provides a framework for understanding distinct expression profiles elicited by different Fc γ-chain-associated receptors." @default.
- W1552948637 created "2016-06-24" @default.
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- W1552948637 date "2004-11-15" @default.
- W1552948637 modified "2023-10-16" @default.
- W1552948637 title "Differential Gene Expression Modulated by the Cytoplasmic Domain of FcγRIa (CD64) α-Chain" @default.
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- W1552948637 doi "https://doi.org/10.4049/jimmunol.173.10.6211" @default.
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