Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553065561> ?p ?o ?g. }
- W1553065561 endingPage "17040" @default.
- W1553065561 startingPage "17029" @default.
- W1553065561 abstract "The P-glycoprotein (P-gp) encoded by the MDR1 gene is a drug-exporting transporter located in the cellular membrane. P-gp induction is regarded as one of the main mechanisms underlying drug-induced resistance. Although there is great interest in the regulation of P-gp expression, little is known about its underlying regulatory mechanisms. In this study, we demonstrate that casein kinase 2 (CK2)-mediated phosphorylation of heat shock protein 90β (Hsp90β) and subsequent stabilization of PXR is a key mechanism in the regulation of MDR1 expression. Furthermore, we show that CK2 is directly activated by rifampin. Upon exposure to rifampin, CK2 catalyzes the phosphorylation of Hsp90β at the Ser-225/254 residues. Phosphorylated Hsp90β then interacts with PXR, causing a subsequent increase in its stability, leading to the induction of P-gp expression. In addition, inhibition of CK2 and Hsp90β enhances the down-regulation of PXR and P-gp expression. The results of this study may facilitate the development of new strategies to prevent multidrug resistance and provide a plausible mechanism for acquired drug resistance by CK2-mediated regulation of P-gp expression." @default.
- W1553065561 created "2016-06-24" @default.
- W1553065561 creator A5002097121 @default.
- W1553065561 creator A5003318164 @default.
- W1553065561 creator A5006904745 @default.
- W1553065561 creator A5011559745 @default.
- W1553065561 creator A5023891207 @default.
- W1553065561 creator A5049335599 @default.
- W1553065561 creator A5051156007 @default.
- W1553065561 creator A5079362020 @default.
- W1553065561 creator A5021063204 @default.
- W1553065561 date "2015-07-01" @default.
- W1553065561 modified "2023-10-14" @default.
- W1553065561 title "Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-induced MDR1 Expression" @default.
- W1553065561 cites W1505612226 @default.
- W1553065561 cites W1516006437 @default.
- W1553065561 cites W1967724297 @default.
- W1553065561 cites W1968535758 @default.
- W1553065561 cites W1972731714 @default.
- W1553065561 cites W1973466091 @default.
- W1553065561 cites W1981873124 @default.
- W1553065561 cites W1982542571 @default.
- W1553065561 cites W1988533633 @default.
- W1553065561 cites W1989013915 @default.
- W1553065561 cites W1996847287 @default.
- W1553065561 cites W1997340004 @default.
- W1553065561 cites W1998495168 @default.
- W1553065561 cites W2003738818 @default.
- W1553065561 cites W2008741099 @default.
- W1553065561 cites W2008785161 @default.
- W1553065561 cites W2022545732 @default.
- W1553065561 cites W2030021013 @default.
- W1553065561 cites W2050041795 @default.
- W1553065561 cites W2059399555 @default.
- W1553065561 cites W2062157293 @default.
- W1553065561 cites W2068229957 @default.
- W1553065561 cites W2068397816 @default.
- W1553065561 cites W2084462922 @default.
- W1553065561 cites W2129881449 @default.
- W1553065561 cites W2135342672 @default.
- W1553065561 cites W2139309160 @default.
- W1553065561 cites W2142540964 @default.
- W1553065561 cites W2148590099 @default.
- W1553065561 cites W2157906581 @default.
- W1553065561 cites W2158207742 @default.
- W1553065561 cites W2168759561 @default.
- W1553065561 cites W2169302611 @default.
- W1553065561 cites W2169923596 @default.
- W1553065561 cites W2557828168 @default.
- W1553065561 doi "https://doi.org/10.1074/jbc.m114.624106" @default.
- W1553065561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4505446" @default.
- W1553065561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25995454" @default.
- W1553065561 hasPublicationYear "2015" @default.
- W1553065561 type Work @default.
- W1553065561 sameAs 1553065561 @default.
- W1553065561 citedByCount "24" @default.
- W1553065561 countsByYear W15530655612015 @default.
- W1553065561 countsByYear W15530655612016 @default.
- W1553065561 countsByYear W15530655612017 @default.
- W1553065561 countsByYear W15530655612018 @default.
- W1553065561 countsByYear W15530655612019 @default.
- W1553065561 countsByYear W15530655612020 @default.
- W1553065561 countsByYear W15530655612021 @default.
- W1553065561 countsByYear W15530655612022 @default.
- W1553065561 crossrefType "journal-article" @default.
- W1553065561 hasAuthorship W1553065561A5002097121 @default.
- W1553065561 hasAuthorship W1553065561A5003318164 @default.
- W1553065561 hasAuthorship W1553065561A5006904745 @default.
- W1553065561 hasAuthorship W1553065561A5011559745 @default.
- W1553065561 hasAuthorship W1553065561A5021063204 @default.
- W1553065561 hasAuthorship W1553065561A5023891207 @default.
- W1553065561 hasAuthorship W1553065561A5049335599 @default.
- W1553065561 hasAuthorship W1553065561A5051156007 @default.
- W1553065561 hasAuthorship W1553065561A5079362020 @default.
- W1553065561 hasBestOaLocation W15530655611 @default.
- W1553065561 hasConcept C104317684 @default.
- W1553065561 hasConcept C111472728 @default.
- W1553065561 hasConcept C11960822 @default.
- W1553065561 hasConcept C138885662 @default.
- W1553065561 hasConcept C143910341 @default.
- W1553065561 hasConcept C160110348 @default.
- W1553065561 hasConcept C184235292 @default.
- W1553065561 hasConcept C185592680 @default.
- W1553065561 hasConcept C205260736 @default.
- W1553065561 hasConcept C2775932338 @default.
- W1553065561 hasConcept C2776142715 @default.
- W1553065561 hasConcept C55493867 @default.
- W1553065561 hasConcept C82495950 @default.
- W1553065561 hasConcept C86803240 @default.
- W1553065561 hasConcept C89611455 @default.
- W1553065561 hasConcept C95444343 @default.
- W1553065561 hasConcept C97029542 @default.
- W1553065561 hasConceptScore W1553065561C104317684 @default.
- W1553065561 hasConceptScore W1553065561C111472728 @default.
- W1553065561 hasConceptScore W1553065561C11960822 @default.
- W1553065561 hasConceptScore W1553065561C138885662 @default.
- W1553065561 hasConceptScore W1553065561C143910341 @default.
- W1553065561 hasConceptScore W1553065561C160110348 @default.