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- W1553084216 abstract "Because PPI therapy reduces stomach acid which theoretically could reduce mineral absorption, this observational study compared measures of bone health biomarkers, bone mineral density (BMD), dietary habits, and physical activity levels of men (n=31) and non-estrogen supplementing post-menopausal women (n=23). Participants were further divided according to duration of proton pump inhibitor (PPI) therapy; more than 5 years (n=16), less than 5 years (n=15), and no PPI therapy (n=23). The shortest duration of PPI therapy was 2 months and the longest duration of PPI therapy was 25 years with a mean duration of 7.5 years. No significant differences were found between measures of spine BMD, urinary deoxypyridinoline (i.e. bone resorption), urinary calcium and magnesium, serum osteocalcin (i.e. bone formation), serum parathyroid hormone, serum magnesium, serum 25 hydroxyvitamin D, dietary and supplement intake, or physical activity levels. However, mean hip BMD was higher in females than in males in participants who took PPI therapy for any duration. In the no-PPI therapy group, hip BMD was not significantly different between genders. This study suggests that there may be no measurable or clinically significant effects of long term PPI therapy on bone health." @default.
- W1553084216 created "2016-06-24" @default.
- W1553084216 creator A5025343005 @default.
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- W1553084216 creator A5042089320 @default.
- W1553084216 creator A5077327765 @default.
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- W1553084216 date "2010-04-01" @default.
- W1553084216 modified "2023-09-23" @default.
- W1553084216 title "Effects of duration of proton pump inhibitor (PPI) therapy on markers of bone health in men and post‐menopausal women" @default.
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