Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553107255> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1553107255 endingPage "116" @default.
- W1553107255 startingPage "103" @default.
- W1553107255 abstract "This chapter describes the genomic organization of the HERC gene, information that should make it possible to detect most mutations related to HERG. The chapter provides the results of mutational analyses of the four known long QT syndrome (LQTS) genes in 45 Japanese families. For patients with clinical symptoms, β-adrenergic blocking agents are the first choice for treatment. Symptoms in about 80% of LQTS patients can be effectively managed with these drugs, but the remaining 20% do not respond. Hence, if the different responses reflect mutations at different sites within a given gene or mutations in different genes, genetic diagnosis might provide information to govern the choice of an appropriate therapeutic approach. In the mutational analyses among 45 Japanese LQTS families, 10 separate and novel HERG mutations were identified. The low frequency of HERC mutations in Japanese LQTS families cannot be attributed mainly to the screening method: polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) generally shows greater than 90% sensitivity." @default.
- W1553107255 created "2016-06-24" @default.
- W1553107255 creator A5041636298 @default.
- W1553107255 creator A5079171795 @default.
- W1553107255 date "1999-01-01" @default.
- W1553107255 modified "2023-10-15" @default.
- W1553107255 title "Chapter 7 Mutational Analysis of Familial Long QT Syndrome in Japan" @default.
- W1553107255 cites W1521731378 @default.
- W1553107255 cites W1976464425 @default.
- W1553107255 cites W1981468825 @default.
- W1553107255 cites W1983137097 @default.
- W1553107255 cites W1988107445 @default.
- W1553107255 cites W1988459796 @default.
- W1553107255 cites W1991662012 @default.
- W1553107255 cites W1997521650 @default.
- W1553107255 cites W1999000941 @default.
- W1553107255 cites W2002422701 @default.
- W1553107255 cites W2003918316 @default.
- W1553107255 cites W2010302358 @default.
- W1553107255 cites W2018150478 @default.
- W1553107255 cites W2022414157 @default.
- W1553107255 cites W2035197728 @default.
- W1553107255 cites W2036194714 @default.
- W1553107255 cites W2038427514 @default.
- W1553107255 cites W2044369084 @default.
- W1553107255 cites W2065288202 @default.
- W1553107255 cites W2073709523 @default.
- W1553107255 cites W2074705578 @default.
- W1553107255 cites W2075164515 @default.
- W1553107255 cites W2080243979 @default.
- W1553107255 cites W2086848699 @default.
- W1553107255 cites W2093214695 @default.
- W1553107255 cites W2094089331 @default.
- W1553107255 cites W2097022235 @default.
- W1553107255 cites W2115149771 @default.
- W1553107255 cites W2117216522 @default.
- W1553107255 cites W2129910735 @default.
- W1553107255 cites W2144423360 @default.
- W1553107255 cites W2167208958 @default.
- W1553107255 cites W2284531888 @default.
- W1553107255 cites W2330959938 @default.
- W1553107255 cites W2411139131 @default.
- W1553107255 cites W2431634234 @default.
- W1553107255 cites W2471757827 @default.
- W1553107255 cites W324747371 @default.
- W1553107255 cites W1975060837 @default.
- W1553107255 doi "https://doi.org/10.1016/s0070-2161(08)60923-5" @default.
- W1553107255 hasPublicationYear "1999" @default.
- W1553107255 type Work @default.
- W1553107255 sameAs 1553107255 @default.
- W1553107255 citedByCount "0" @default.
- W1553107255 crossrefType "book-chapter" @default.
- W1553107255 hasAuthorship W1553107255A5041636298 @default.
- W1553107255 hasAuthorship W1553107255A5079171795 @default.
- W1553107255 hasConcept C104317684 @default.
- W1553107255 hasConcept C118441451 @default.
- W1553107255 hasConcept C126322002 @default.
- W1553107255 hasConcept C129219603 @default.
- W1553107255 hasConcept C2779362680 @default.
- W1553107255 hasConcept C2779703243 @default.
- W1553107255 hasConcept C501734568 @default.
- W1553107255 hasConcept C54355233 @default.
- W1553107255 hasConcept C71924100 @default.
- W1553107255 hasConcept C83743174 @default.
- W1553107255 hasConcept C86803240 @default.
- W1553107255 hasConceptScore W1553107255C104317684 @default.
- W1553107255 hasConceptScore W1553107255C118441451 @default.
- W1553107255 hasConceptScore W1553107255C126322002 @default.
- W1553107255 hasConceptScore W1553107255C129219603 @default.
- W1553107255 hasConceptScore W1553107255C2779362680 @default.
- W1553107255 hasConceptScore W1553107255C2779703243 @default.
- W1553107255 hasConceptScore W1553107255C501734568 @default.
- W1553107255 hasConceptScore W1553107255C54355233 @default.
- W1553107255 hasConceptScore W1553107255C71924100 @default.
- W1553107255 hasConceptScore W1553107255C83743174 @default.
- W1553107255 hasConceptScore W1553107255C86803240 @default.
- W1553107255 hasLocation W15531072551 @default.
- W1553107255 hasOpenAccess W1553107255 @default.
- W1553107255 hasPrimaryLocation W15531072551 @default.
- W1553107255 hasRelatedWork W1967155153 @default.
- W1553107255 hasRelatedWork W2008885898 @default.
- W1553107255 hasRelatedWork W2029047959 @default.
- W1553107255 hasRelatedWork W2029811900 @default.
- W1553107255 hasRelatedWork W2100559057 @default.
- W1553107255 hasRelatedWork W2257611137 @default.
- W1553107255 hasRelatedWork W2348422094 @default.
- W1553107255 hasRelatedWork W2390512674 @default.
- W1553107255 hasRelatedWork W2905980605 @default.
- W1553107255 hasRelatedWork W4229836094 @default.
- W1553107255 isParatext "false" @default.
- W1553107255 isRetracted "false" @default.
- W1553107255 magId "1553107255" @default.
- W1553107255 workType "book-chapter" @default.