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- W1553171739 abstract "This chapter provides a history of genetic toxicology, a description of the most commonly used regulatory tests, and an overview of international regulatory guidelines—most of which are accepted by regulatory agencies in the United States. Genetic toxicology tests are designed to detect chemical agents capable of damaging DNA and chromosomes of cells. Furthermore, genetic toxicology tests are an integral part of the toxicological evaluation of chemicals for adverse human health effects, especially cancer. The most commonly used regulatory genetic toxicology tests are a series of well-characterized mutagenicity tests, which include in vitro bacterial and mammalian assays, as well as in vivo mammalian assays. They have a high predictive value for rodent carcinogenicity. However, these tests should not be used as a substitute for rodent carcinogenicity studies. They should be used to determine the spectrum of genetic effects of specific chemicals and to aid in the interpretation of genetic toxicity test results." @default.
- W1553171739 created "2016-06-24" @default.
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- W1553171739 date "2004-01-01" @default.
- W1553171739 modified "2023-10-16" @default.
- W1553171739 title "Current Issues in Genetic Toxicology Testing for Microbiologists" @default.
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- W1553171739 doi "https://doi.org/10.1016/s0065-2164(04)56012-4" @default.
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