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- W1553175311 abstract "客观：计算表达式和 multidrug 抵抗基因(mdr1 ) 和 multidrug 的临床的意义在尖锐白血病的联系抵抗的蛋白质(MRP ) 基因。方法：在有由反向的抄写聚合酶链反应(RT-PCR ) 的尖锐白血病(AL ) 的 55 个病人的 mdr1 和 MRP 试金的表示。结果：在 relapsed AL 和电流型逻辑的 blastic 塑料阶段的 mdr1 和 MRP 基因表达式层次比在最新诊断的 AL 和控制的那些显著地高。在临床的药抵抗的组的 mdr1 和 MRP 基因表示层次比在 non-drug-resistant 组的那些显著地高。在有高 mdr1 表示(14.3%) 的病人的完全的宽恕(CR ) 率与低 mdr1 表示(57.5%) 是比那显著地低的；同样，在水平也是的有高 MRP 的病人的 CR 率与低 MRP 水平比那降低。当为评估 multidrug 抵抗(MDR ) 的指示物，积极预兆的价值和精确性高与单个基因比较增加了，两个都使用 mdr1 和 MRP 基因的高表示表示。结论：mdr1 或 MRP 基因表示的提高的水平可能是为耐心的 AL 的相反的预示的因素并且可以作为一个重要索引被使用在 AL 病人预言药抵抗和恶化。测量 mdr1 和 MRP 基因表示将增加在尖锐白血病评估 MDR 的精确性和敏感。" @default.
- W1553175311 created "2016-06-24" @default.
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- W1553175311 date "1999-01-01" @default.
- W1553175311 modified "2023-09-24" @default.
- W1553175311 title "EXPRESSION AND CLINICAL SIGNIFICANCE OF MULTIDRUG RESISTANCE GENE AND MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN GENE IN ACUTE LEUKEMIA" @default.
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