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- W1553212487 abstract "Objective:The aim of our study was to analyze the frequency of early neurological worsening in WD patients, its outcome, clinical and laboratory factors which may impact it.Background: Early neurological worsening during initiation of Wilson’s Disease (WD)treatment is still an unresolved therapeutic problem.Methods: We analyzed 143 symptomatic WD patients, diagnosed between 2005- 2010. The early neurological deterioration group was based on worsening in Unified Wilson’s Disease Score Scale (UWDRS) scored at baseline till 6 months or occurrence of new neurological symptoms. Reversibility of worsening was followed-up to 24 months. Further the analysis were performed in subgroups with and without neurological worsening according to selected clinical and laboratory variables and type of anti-copper therapy.Results: Early neurological worsening in 11.1 [percnt](16/143)of WD patients, only in patients with neurological signs at diagnosis.The mean time of worsening since WD treatment began was 2,3±1.9 months.The neurological deterioration was completely reversible in 53[percnt](8/15)and partially in 13[percnt] (2/15) patients during 9.2±5.2 months.The gender, age of diagnosis, disease duration, kind of WD treatment(D-penicillamine or zinc sulphate),kind of neurological manifestations, initial copper metabolism results as well as liver functions parameters had no impact on early neurological worsening. Baseline neurological symptoms (15/69 vs.0/73;p<0.01);advance of neurological deficits scored in UWDRS part II and III(p<0.01); the occurrence of brain magnetic resonance imaging (MRI) changes due to WD in thalamus(p<0.01)and brain stem(p<0.01); the concomitant treatment with drugs potentially modulating the action of dopamine (p<0.05),were the main predictors of early neurological deterioration in WD patients.Conclusions: Neurological worsening at the beginning of the anti-copper therapy in WD patients occur in patients with severe initial neurological manifestation, advanced brain injury and may be also provoked by concomitant treatment, but it is not associated with the type of anticopper therapy. Disclosure: Dr. Czlonkowska has nothing to disclose. Dr. Litwin has nothing to disclose. Dr. Karlinski has nothing to disclose. Dr. Dziezyc has nothing to disclose." @default.
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- W1553212487 date "2015-04-06" @default.
- W1553212487 modified "2023-10-14" @default.
- W1553212487 title "Early neurological worsening in Wilson’s Disease patients. (P7.285)" @default.
- W1553212487 hasPublicationYear "2015" @default.
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