Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553283585> ?p ?o ?g. }
- W1553283585 abstract "Abstract Immunotoxicity can manifest as an exaggerated immune response to a normally innocuous substance and lead to hypersensitivity or allergic reactions in the lung. Allergens are encountered environmentally or in the workplace and can be low‐ and high‐molecular‐weight substances. Allergic asthma and allergic rhinitis are examples of allergic reactions in the lung with immediate, late and chronic phases contributing to respiratory tract pathology. Mechanistically, allergic asthma and rhinitis reflect a combination of antibody and cell‐mediated immune reactions involving IgE antibody to allergen in the early stages and Th2 cell involvement as the disease progresses to late‐phase reactions and chronic allergic inflammation. Multiple cell types and mediators are involved in the inflammatory response in the lung. Mechanistic differences leading to the asthma/rhinitis phenotype have been noted with different allergens, primarily low‐molecular‐weight substances. Xenobiotics that are not allergens themselves may enhance the immune response to allergens or exacerbate pre‐existing asthma and airway hyper‐responsiveness. The complexity of the allergic response in terms of humoral and cell‐mediated immunity, as well as potential differences in mechanisms depending on the allergen, present a very challenging scenario for the toxicologist to predict the exposures that will result in allergic rhinitis or asthma." @default.
- W1553283585 created "2016-06-24" @default.
- W1553283585 creator A5091607844 @default.
- W1553283585 date "2009-10-23" @default.
- W1553283585 modified "2023-10-12" @default.
- W1553283585 title "Allergic Asthma and Rhinitis: Toxicological Considerations" @default.
- W1553283585 cites W1538518781 @default.
- W1553283585 cites W1548360264 @default.
- W1553283585 cites W1668088982 @default.
- W1553283585 cites W1731104758 @default.
- W1553283585 cites W1826685680 @default.
- W1553283585 cites W1912949881 @default.
- W1553283585 cites W1963688598 @default.
- W1553283585 cites W1967674599 @default.
- W1553283585 cites W1968080971 @default.
- W1553283585 cites W1971328564 @default.
- W1553283585 cites W1971636564 @default.
- W1553283585 cites W1971860422 @default.
- W1553283585 cites W1975464178 @default.
- W1553283585 cites W1975696541 @default.
- W1553283585 cites W1976940392 @default.
- W1553283585 cites W1977074923 @default.
- W1553283585 cites W1977885071 @default.
- W1553283585 cites W1978350581 @default.
- W1553283585 cites W1990299371 @default.
- W1553283585 cites W1990440885 @default.
- W1553283585 cites W1993085864 @default.
- W1553283585 cites W1993668404 @default.
- W1553283585 cites W1994342455 @default.
- W1553283585 cites W1994367484 @default.
- W1553283585 cites W1996587607 @default.
- W1553283585 cites W2000167866 @default.
- W1553283585 cites W2000611850 @default.
- W1553283585 cites W2002375125 @default.
- W1553283585 cites W2002427025 @default.
- W1553283585 cites W2004757054 @default.
- W1553283585 cites W2005743710 @default.
- W1553283585 cites W2007949618 @default.
- W1553283585 cites W2013377406 @default.
- W1553283585 cites W2016305205 @default.
- W1553283585 cites W2017017262 @default.
- W1553283585 cites W2021982282 @default.
- W1553283585 cites W2022306839 @default.
- W1553283585 cites W2023843961 @default.
- W1553283585 cites W2024156716 @default.
- W1553283585 cites W2027509080 @default.
- W1553283585 cites W2028745370 @default.
- W1553283585 cites W2030434456 @default.
- W1553283585 cites W2035238376 @default.
- W1553283585 cites W2035632341 @default.
- W1553283585 cites W2037248729 @default.
- W1553283585 cites W2039435710 @default.
- W1553283585 cites W2040543447 @default.
- W1553283585 cites W2047355895 @default.
- W1553283585 cites W2049202532 @default.
- W1553283585 cites W2052227203 @default.
- W1553283585 cites W2052444283 @default.
- W1553283585 cites W2052628757 @default.
- W1553283585 cites W2054639404 @default.
- W1553283585 cites W2055293820 @default.
- W1553283585 cites W2058385880 @default.
- W1553283585 cites W2065340743 @default.
- W1553283585 cites W2065514618 @default.
- W1553283585 cites W2066874407 @default.
- W1553283585 cites W2067867776 @default.
- W1553283585 cites W2068361114 @default.
- W1553283585 cites W2068643209 @default.
- W1553283585 cites W2069457400 @default.
- W1553283585 cites W2076100315 @default.
- W1553283585 cites W2078131311 @default.
- W1553283585 cites W2086782209 @default.
- W1553283585 cites W2086930861 @default.
- W1553283585 cites W2087257927 @default.
- W1553283585 cites W2087440217 @default.
- W1553283585 cites W2088661593 @default.
- W1553283585 cites W2088871073 @default.
- W1553283585 cites W2092192775 @default.
- W1553283585 cites W2097702927 @default.
- W1553283585 cites W2097901958 @default.
- W1553283585 cites W2098204210 @default.
- W1553283585 cites W2105407265 @default.
- W1553283585 cites W2107207387 @default.
- W1553283585 cites W2108139380 @default.
- W1553283585 cites W2109572896 @default.
- W1553283585 cites W2109865874 @default.
- W1553283585 cites W2109963121 @default.
- W1553283585 cites W2109989887 @default.
- W1553283585 cites W2110673488 @default.
- W1553283585 cites W2111578594 @default.
- W1553283585 cites W2112249469 @default.
- W1553283585 cites W2112358708 @default.
- W1553283585 cites W2114008130 @default.
- W1553283585 cites W2116809392 @default.
- W1553283585 cites W2120588301 @default.
- W1553283585 cites W2128881831 @default.
- W1553283585 cites W2129922473 @default.
- W1553283585 cites W2134204376 @default.
- W1553283585 cites W2135409837 @default.
- W1553283585 cites W2137473548 @default.
- W1553283585 cites W2139618618 @default.