Matches in SemOpenAlex for { <https://semopenalex.org/work/W155328677> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W155328677 endingPage "55.1" @default.
- W155328677 startingPage "55.1" @default.
- W155328677 abstract "Abstract Periostin is a 90kD member of the fasciclin-containing family and functions as part of the extracellular matrix. Periostin is expressed in a variety of tissues and expression is increased in airway epithelial cells from asthmatic patients. Recent studies have implicated a role for periostin in allergic eosinophilic esophagitis. To further define a role for periostin in Th2-mediated inflammatory diseases such as asthma, we studied the development of allergic pulmonary inflammation in periostin-deficient mice. Sensitization and challenge of periostin-deficient mice with ovalbumin resulted in increased peripheral Th2 responses compared to control mice. In the lungs, periostin-deficiency resulted in increased airway resistance and significantly enhanced mucus production by goblet cells concomitant with increased expression of Gob5 and Muc5ac, compared to wild type littermates. Importantly, the physiological significance of the function of periostin is demonstrated by its ability to inhibit the expression of Gob5, a putative calcium-activated chloride channel involved in the regulation of mucus production, in primary murine airway epithelial cells. Our studies suggest that periostin may be part of a negative-feedback loop regulating allergic inflammation that could serve as a therapeutic target in the treatment of atopic disease." @default.
- W155328677 created "2016-06-24" @default.
- W155328677 creator A5001314504 @default.
- W155328677 creator A5026411789 @default.
- W155328677 creator A5030785720 @default.
- W155328677 creator A5038146016 @default.
- W155328677 creator A5053295938 @default.
- W155328677 creator A5089857516 @default.
- W155328677 date "2011-04-01" @default.
- W155328677 modified "2023-09-25" @default.
- W155328677 title "A role for periostin in regulation of goblet cell metaplasia (55.1)" @default.
- W155328677 doi "https://doi.org/10.4049/jimmunol.186.supp.55.1" @default.
- W155328677 hasPublicationYear "2011" @default.
- W155328677 type Work @default.
- W155328677 sameAs 155328677 @default.
- W155328677 citedByCount "0" @default.
- W155328677 crossrefType "journal-article" @default.
- W155328677 hasAuthorship W155328677A5001314504 @default.
- W155328677 hasAuthorship W155328677A5026411789 @default.
- W155328677 hasAuthorship W155328677A5030785720 @default.
- W155328677 hasAuthorship W155328677A5038146016 @default.
- W155328677 hasAuthorship W155328677A5053295938 @default.
- W155328677 hasAuthorship W155328677A5089857516 @default.
- W155328677 hasConcept C126322002 @default.
- W155328677 hasConcept C142724271 @default.
- W155328677 hasConcept C18903297 @default.
- W155328677 hasConcept C189165786 @default.
- W155328677 hasConcept C203014093 @default.
- W155328677 hasConcept C2775941134 @default.
- W155328677 hasConcept C2776914184 @default.
- W155328677 hasConcept C2776946954 @default.
- W155328677 hasConcept C2777312293 @default.
- W155328677 hasConcept C2777699602 @default.
- W155328677 hasConcept C2779357193 @default.
- W155328677 hasConcept C2779675166 @default.
- W155328677 hasConcept C529295009 @default.
- W155328677 hasConcept C71924100 @default.
- W155328677 hasConcept C86803240 @default.
- W155328677 hasConcept C8891405 @default.
- W155328677 hasConcept C95444343 @default.
- W155328677 hasConceptScore W155328677C126322002 @default.
- W155328677 hasConceptScore W155328677C142724271 @default.
- W155328677 hasConceptScore W155328677C18903297 @default.
- W155328677 hasConceptScore W155328677C189165786 @default.
- W155328677 hasConceptScore W155328677C203014093 @default.
- W155328677 hasConceptScore W155328677C2775941134 @default.
- W155328677 hasConceptScore W155328677C2776914184 @default.
- W155328677 hasConceptScore W155328677C2776946954 @default.
- W155328677 hasConceptScore W155328677C2777312293 @default.
- W155328677 hasConceptScore W155328677C2777699602 @default.
- W155328677 hasConceptScore W155328677C2779357193 @default.
- W155328677 hasConceptScore W155328677C2779675166 @default.
- W155328677 hasConceptScore W155328677C529295009 @default.
- W155328677 hasConceptScore W155328677C71924100 @default.
- W155328677 hasConceptScore W155328677C86803240 @default.
- W155328677 hasConceptScore W155328677C8891405 @default.
- W155328677 hasConceptScore W155328677C95444343 @default.
- W155328677 hasIssue "1_Supplement" @default.
- W155328677 hasLocation W1553286771 @default.
- W155328677 hasOpenAccess W155328677 @default.
- W155328677 hasPrimaryLocation W1553286771 @default.
- W155328677 hasRelatedWork W155328677 @default.
- W155328677 hasRelatedWork W2017212450 @default.
- W155328677 hasRelatedWork W2118506618 @default.
- W155328677 hasRelatedWork W2121431809 @default.
- W155328677 hasRelatedWork W2127328506 @default.
- W155328677 hasRelatedWork W2154271021 @default.
- W155328677 hasRelatedWork W2971823582 @default.
- W155328677 hasRelatedWork W3029300228 @default.
- W155328677 hasRelatedWork W3197055271 @default.
- W155328677 hasRelatedWork W4384501952 @default.
- W155328677 hasVolume "186" @default.
- W155328677 isParatext "false" @default.
- W155328677 isRetracted "false" @default.
- W155328677 magId "155328677" @default.
- W155328677 workType "article" @default.