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- W1553286968 abstract "ATPsensitive potassium (KATP) channels first discovered in cardiac myocytes in 1983 (Noma, 1983), and then found in many other metabolically active tissues, including central nervous systems (Babenko et al., 1998). KATP channels are inhibited by physiological concentration of intracellular ATP, and are activated when the intracellular ADP/ATP ratio increases secondary to hypoxia, ischemia, or metabolic stress (Babenko et al., 1998; Miki & Seino, 2005; Nichols, 2006). The activation of KATP channels results in an enhanced outward repolarizing flow of K+ and cell membrane hyperpolarization, and thus they regulate cell excitability and mediate cellular responses that determine cell survival during metabolic stress (Miki & Seino, 2005)." @default.
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- W1553286968 date "2012-03-23" @default.
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- W1553286968 title "Single-Channel Properties and Pharmacological Characteristics of KATP Channels in Primary Afferent Neurons" @default.
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- W1553286968 doi "https://doi.org/10.5772/34824" @default.
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