Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553293727> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1553293727 endingPage "6" @default.
- W1553293727 startingPage "2773" @default.
- W1553293727 abstract "Murine monoclonal antibodies (MAB) of the IgG3 subclass generated to colorectal tumor-associated glycolipids were assessed for enhancement of antibody-dependent cell-mediated cytotoxicity (ADCC) by interleukin 2 (IL-2). Mononuclear cell preparations containing large granular lymphocyte effectors required only low doses of IL-2 (0.1-10 units/ml) and short exposure (3 h) for maximal enhancement of ADCC. Exposure of mononuclear cells for longer periods (1-6 days) to higher levels of IL-2 (100-1000 units/ml) resulted in the generation of lymphokine-activated killer N cells which were lytically active without antibody. A non-ADCC MAB of the IgG1 subclass showed no ADCC even after stimulation of effector cells with IL-2. Effector cells pretreated with IL-2 showed an enhanced rate of cytolysis of target cells in the presence of antibody. Pretreatment of effector cells with IgG3 MAB resulted in lower ADCC, but pretreatment of target cells or simultaneous addition of MAB and effectors to target cells gave higher levels. These results indicated that ADCC with murine IgG3 is enhanced by levels of IL-2 achievable in current patient trials. The combination of antibody and IL-2-boosted effector cells gives comparable levels of killing to lymphokine-activated killer cells but should not suffer from similar toxicity. The NR-Co-04 antibody in combination with lymphokine may prove effective in treating colon cancer, a disease for which both chemotherapeutic and current biological therapies suggest a need for improved forms of therapies." @default.
- W1553293727 created "2016-06-24" @default.
- W1553293727 creator A5022960930 @default.
- W1553293727 creator A5023829580 @default.
- W1553293727 creator A5026460436 @default.
- W1553293727 creator A5066301390 @default.
- W1553293727 date "1989-05-15" @default.
- W1553293727 modified "2023-09-23" @default.
- W1553293727 title "Murine monoclonal IgG3 to human colorectal tumor-associated antigens: enhancement of antibody-dependent cell-mediated cytotoxicity by interleukin 2." @default.
- W1553293727 cites W1678686630 @default.
- W1553293727 cites W1811369566 @default.
- W1553293727 cites W1951179504 @default.
- W1553293727 cites W1962165904 @default.
- W1553293727 cites W2016292927 @default.
- W1553293727 cites W2052214675 @default.
- W1553293727 cites W2060816503 @default.
- W1553293727 cites W2068441417 @default.
- W1553293727 cites W2074627681 @default.
- W1553293727 cites W2081549751 @default.
- W1553293727 cites W2113009157 @default.
- W1553293727 cites W2113433721 @default.
- W1553293727 cites W2113973363 @default.
- W1553293727 cites W2128285319 @default.
- W1553293727 cites W2400883416 @default.
- W1553293727 cites W2406505455 @default.
- W1553293727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2785437" @default.
- W1553293727 hasPublicationYear "1989" @default.
- W1553293727 type Work @default.
- W1553293727 sameAs 1553293727 @default.
- W1553293727 citedByCount "10" @default.
- W1553293727 crossrefType "journal-article" @default.
- W1553293727 hasAuthorship W1553293727A5022960930 @default.
- W1553293727 hasAuthorship W1553293727A5023829580 @default.
- W1553293727 hasAuthorship W1553293727A5026460436 @default.
- W1553293727 hasAuthorship W1553293727A5066301390 @default.
- W1553293727 hasConcept C109316439 @default.
- W1553293727 hasConcept C137061746 @default.
- W1553293727 hasConcept C147483822 @default.
- W1553293727 hasConcept C153911025 @default.
- W1553293727 hasConcept C159654299 @default.
- W1553293727 hasConcept C202751555 @default.
- W1553293727 hasConcept C203014093 @default.
- W1553293727 hasConcept C2777371288 @default.
- W1553293727 hasConcept C2777761686 @default.
- W1553293727 hasConcept C2778690821 @default.
- W1553293727 hasConcept C40677261 @default.
- W1553293727 hasConcept C49382859 @default.
- W1553293727 hasConcept C502942594 @default.
- W1553293727 hasConcept C51785407 @default.
- W1553293727 hasConcept C542903549 @default.
- W1553293727 hasConcept C55493867 @default.
- W1553293727 hasConcept C86803240 @default.
- W1553293727 hasConceptScore W1553293727C109316439 @default.
- W1553293727 hasConceptScore W1553293727C137061746 @default.
- W1553293727 hasConceptScore W1553293727C147483822 @default.
- W1553293727 hasConceptScore W1553293727C153911025 @default.
- W1553293727 hasConceptScore W1553293727C159654299 @default.
- W1553293727 hasConceptScore W1553293727C202751555 @default.
- W1553293727 hasConceptScore W1553293727C203014093 @default.
- W1553293727 hasConceptScore W1553293727C2777371288 @default.
- W1553293727 hasConceptScore W1553293727C2777761686 @default.
- W1553293727 hasConceptScore W1553293727C2778690821 @default.
- W1553293727 hasConceptScore W1553293727C40677261 @default.
- W1553293727 hasConceptScore W1553293727C49382859 @default.
- W1553293727 hasConceptScore W1553293727C502942594 @default.
- W1553293727 hasConceptScore W1553293727C51785407 @default.
- W1553293727 hasConceptScore W1553293727C542903549 @default.
- W1553293727 hasConceptScore W1553293727C55493867 @default.
- W1553293727 hasConceptScore W1553293727C86803240 @default.
- W1553293727 hasIssue "10" @default.
- W1553293727 hasLocation W15532937271 @default.
- W1553293727 hasOpenAccess W1553293727 @default.
- W1553293727 hasPrimaryLocation W15532937271 @default.
- W1553293727 hasRelatedWork W1479978113 @default.
- W1553293727 hasRelatedWork W198918843 @default.
- W1553293727 hasRelatedWork W2036200948 @default.
- W1553293727 hasRelatedWork W2061891405 @default.
- W1553293727 hasRelatedWork W2065097070 @default.
- W1553293727 hasRelatedWork W2339482712 @default.
- W1553293727 hasRelatedWork W2418656659 @default.
- W1553293727 hasRelatedWork W2476973230 @default.
- W1553293727 hasRelatedWork W2986792671 @default.
- W1553293727 hasRelatedWork W2411078256 @default.
- W1553293727 hasVolume "49" @default.
- W1553293727 isParatext "false" @default.
- W1553293727 isRetracted "false" @default.
- W1553293727 magId "1553293727" @default.
- W1553293727 workType "article" @default.