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- W1553331373 abstract "Abstract : This study explores beta-adrenoceptors on breast cancer cells as a therapeutic target. MDA-MB-23 1 human breast cancer cells express high beta2-adrenoceptor levels that are linked to inhibition of mitosis through the production of cyclic AMP. The phosphodiesterase inhibitor, theophylline, reduced cell number and altered cellular morphology. In the current year, we evaluated the evaluated the effects of theophylline on macromolecule synthesis and indices of cell viability. Theophylline evoked a concentration- and time-dependent decrease in DNA synthesis. However, the decrease in cell number was greater than that predicted from mitotic arrest. Assessment of protein synthesis indicated a second effect separable from that on DNA synthesis; this was confirmed by decreased cell viability and adhesion. Exposure to the phosphodiesterase inhibitor, IBMX, in concentrations that produced inhibition of DNA synthesis equivalent to that seen with theophylline, elicited a smaller reduction in cell number. Theophylline also evoked specific changes in the expression or function of membrane-bound adenylyl cyclase activity, effects that are likely to contribute to sustained reactivity of these cells to other cAMP-related inhibitors of cell proliferation, such as isoproterenol. The multiple pharmacologic properties of theophylline, producing mitotic inhibition, cytotoxicity and altered signaling in MDA-MB-23 1 cells provide insight ht into novel therapeutic strategies." @default.
- W1553331373 created "2016-06-24" @default.
- W1553331373 creator A5000464378 @default.
- W1553331373 date "2001-07-01" @default.
- W1553331373 modified "2023-09-24" @default.
- W1553331373 title "Beta-Adrenergic Receptors Regulating Growth and Replication of Breast Cancer cells: Basic and Therapeutic Implications" @default.
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- W1553331373 doi "https://doi.org/10.21236/ada395273" @default.
- W1553331373 hasPublicationYear "2001" @default.
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