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• W1553365749 endingPage "19463" @default.
• W1553365749 startingPage "19455" @default.
• W1553365749 abstract "Numerous studies have indicated that cytoplasmic intermediate filaments (cIFs) can associate with cellular lipids. To determine if these interactions might have functional consequences, we have studied the lipid metabolism of human SW-13 adrenal tumor cell lines that either contain vimentin-type cIFs (vim+) or lack any detectable cIF network (vim-). Although there were no significant differences in phospholipid or glyceride synthesis, vim- cell lines had elevated levels of cholesterol synthesis and decreased cholesterol esterification, compared with vim+ cells. These differences in cholesterol synthesis and esterification were found to be due to an impaired ability of vim- cells to utilize low density lipoprotein (LDL)-derived cholesterol, although receptor-mediated endocytosis of LDL and the capacity of these cells to esterify endogenously produced cholesterol were not affected. Expression of a mouse vimentin cDNA in stably transfected cell lines, derived from vim- cells, restored the capacity of these cells to utilize LDL cholesterol. The uptake and metabolism of [3H]cholesterol linoleate-loaded LDL showed that the impaired ability of vim- cells to esterify LDL cholesterol was not associated with an accumulation of cellular free cholesterol but rather an increase in the appearance of [3H]cholesterol in the culture medium. These studies indicate that in SW-13 cells, the intracellular movement of LDL-derived cholesterol from the lysosome to the site of esterification is a vimentin-dependent process." @default.
• W1553365749 created "2016-06-24" @default.
• W1553365749 creator A5014269199 @default.
• W1553365749 creator A5024127409 @default.
• W1553365749 creator A5084883300 @default.
• W1553365749 date "1992-09-01" @default.
• W1553365749 modified "2023-10-18" @default.
• W1553365749 title "A functional role for vimentin intermediate filaments in the metabolism of lipoprotein-derived cholesterol in human SW-13 cells." @default.
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• W1553365749 doi "https://doi.org/10.1016/s0021-9258(18)41797-8" @default.
• W1553365749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1527066" @default.
• W1553365749 hasPublicationYear "1992" @default.
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