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- W1553424707 abstract "A facile, efficient, solvent-free method for the synthesis of phosphocholines and lyso phosphocholines in excellent yields has been developed employing sn-glycero-3-phosphocholine-kieselguhr complex with shorter reaction times with the recycling of kieselguhr for further use. Fatty acids with chain lengths C3–C6 and C8–C18 formed 1,2-diacyl-sn-glycero-3-phosphocholines and 1-acyl-sn-glycero-3-phosphocholines respectively. Fatty acid chlorides (C3–C18) resulted exclusively in 1,2-diacyl-sn-glycero-3-phosphocholines. Practical applications: Synthetic methodology for the synthesis of symmetrical phosphatidylcholines is described. The described method uses kieselguhr as a catalyst and reagent which can be recycled after the reaction. By this method gram quantities of phosphatidylcholines can be prepared without the use of any other acylating reagents. The synthetic method is a novel approach for producing phosphatidylcholines and lysophosphatidylcholines which have wide range of applications. Synthesis of 1-acyl-sn-glycero-3-phosphocholine and 1,2-diacyl-sn-glycero-3-phosphocholine." @default.
- W1553424707 created "2016-06-24" @default.
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- W1553424707 date "2015-02-09" @default.
- W1553424707 modified "2023-09-25" @default.
- W1553424707 title "A novel method to synthesize 1‐acyl‐ <i>sn</i> ‐glycero‐3‐phosphocholine and 1,2‐diacyl‐ <i>sn</i> ‐glycero‐3‐phosphocholine" @default.
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- W1553424707 doi "https://doi.org/10.1002/ejlt.201400615" @default.
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