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- W1553447776 abstract "Nausea and vomiting are well known side effects related to chemotherapy. Indeed, nauseaand vomiting are the most distressing side effects of chemotherapy in cancer patients.Dopamine, serotonin and neurokinin1 are thought to be the neurotransmitters that playrole in the pathophysiology of Chemotherapy Induced Nausea Vomiting (CINV). Thus, theantagonists of those neurotransmitters are considered as prophylactic antiemetics for CINV.In the 1990s, the use of 5-Hydroxytriptamine receptor antagonists (5-HT3RAs) highlyimproved the patients’ response rate to antiemetic drugs. In addition, the combination of aneurokinin 1 antagonist, a 5HT3RA and a corticosteroid can further increase the responserate up by 15% in acute phase and 20% in delayed phase. Thus, the international guidelineof clinical oncology recommend this combination as prophylactic antiemetic drugs inthe acute phase and a combination of dexamethasone – metoclopramide as prophylacticantiemetics in the delayed phase.However, when the standard antiemetic drug regimens are administered to patients,there are still 20-30% patients in the acute phase and 40% patients in the delayed phaseexperiencing CINV. Thus, there is a high interindividual variability in response toantiemetic drugs in oncology patients. Some patient characteristics such as female gender,younger patients and history of alcohol drinking could increase the risk of CINV from 20%to 70%. Therefore, individualizing of the use of antiemetics could start by considering thepatient characteristics. This thesis focuses on determining the impact of CINV on QoLin Indonesian cancer patients and optimizing the prevention and treatment of CINV byexploration of pharmacogenetic biomarkers." @default.
- W1553447776 created "2016-06-24" @default.
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- W1553447776 date "2009-01-01" @default.
- W1553447776 modified "2023-09-24" @default.
- W1553447776 title "Pharmacogenetics of Antiemetics in Indonesian Cancer Patients" @default.
- W1553447776 hasPublicationYear "2009" @default.
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