Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553529648> ?p ?o ?g. }
- W1553529648 endingPage "797" @default.
- W1553529648 startingPage "789" @default.
- W1553529648 abstract "A previous clinical trial demonstrated that four months of treatment with intranasal insulin improves cognition and function for patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI), but prior studies suggest that response to insulin treatment may differ by sex and ApoE ε4 carriage. Thus, responder analyses using repeated measures analysis of covariance were completed on the trial's 104 participants with MCI or AD who received either placebo or 20 or 40 IU of insulin for 4 months, administered by a nasal delivery device. Results indicate that men and women with memory impairment responded differently to intranasal insulin treatment. On delayed story memory, men and women showed cognitive improvement when taking 20 IU of intranasal insulin, but only men showed cognitive improvement for the 40 IU dose. The sex difference was most apparent for ApoE ε4 negative individuals. For the 40 IU dose, ApoE ε4 negative men improved while ApoE ε4 negative women worsened. Their ApoE ε4 positive counterparts remained cognitively stable. This sex effect was not detected in functional measures. However, functional abilities were relatively preserved for women on either dose of intranasal insulin compared with men. Unlike previous studies with young adults, neither men nor women taking intranasal insulin exhibited a significant change in weight over 4 months of treatment." @default.
- W1553529648 created "2016-06-24" @default.
- W1553529648 creator A5013988493 @default.
- W1553529648 creator A5019308143 @default.
- W1553529648 creator A5023928454 @default.
- W1553529648 creator A5044893402 @default.
- W1553529648 creator A5047242201 @default.
- W1553529648 creator A5051182952 @default.
- W1553529648 creator A5059786842 @default.
- W1553529648 creator A5067701288 @default.
- W1553529648 creator A5071161054 @default.
- W1553529648 creator A5083841367 @default.
- W1553529648 date "2013-05-21" @default.
- W1553529648 modified "2023-10-11" @default.
- W1553529648 title "Sex and ApoE Genotype Differences in Treatment Response to Two Doses of Intranasal Insulin in Adults with Mild Cognitive Impairment or Alzheimer's Disease" @default.
- W1553529648 cites W1481733466 @default.
- W1553529648 cites W1527910050 @default.
- W1553529648 cites W1546369396 @default.
- W1553529648 cites W1718410121 @default.
- W1553529648 cites W1953027527 @default.
- W1553529648 cites W1953255974 @default.
- W1553529648 cites W1965520272 @default.
- W1553529648 cites W1967564647 @default.
- W1553529648 cites W1968307217 @default.
- W1553529648 cites W1977031758 @default.
- W1553529648 cites W1981205792 @default.
- W1553529648 cites W1986144956 @default.
- W1553529648 cites W1992431456 @default.
- W1553529648 cites W1995491925 @default.
- W1553529648 cites W1996776294 @default.
- W1553529648 cites W2007895806 @default.
- W1553529648 cites W2015016479 @default.
- W1553529648 cites W2019159227 @default.
- W1553529648 cites W2020780341 @default.
- W1553529648 cites W2031791496 @default.
- W1553529648 cites W2033411034 @default.
- W1553529648 cites W2043768383 @default.
- W1553529648 cites W2046140771 @default.
- W1553529648 cites W2047509507 @default.
- W1553529648 cites W2056014943 @default.
- W1553529648 cites W2075668179 @default.
- W1553529648 cites W2083337622 @default.
- W1553529648 cites W2086190854 @default.
- W1553529648 cites W2090881453 @default.
- W1553529648 cites W2092970457 @default.
- W1553529648 cites W2095197912 @default.
- W1553529648 cites W2101048381 @default.
- W1553529648 cites W2105599846 @default.
- W1553529648 cites W2111765180 @default.
- W1553529648 cites W2127705453 @default.
- W1553529648 cites W2131760568 @default.
- W1553529648 cites W2139307317 @default.
- W1553529648 cites W2153284686 @default.
- W1553529648 cites W2156220037 @default.
- W1553529648 cites W2157247104 @default.
- W1553529648 cites W2158662933 @default.
- W1553529648 cites W2162116935 @default.
- W1553529648 cites W2168769697 @default.
- W1553529648 cites W2193764494 @default.
- W1553529648 doi "https://doi.org/10.3233/jad-122308" @default.
- W1553529648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4144993" @default.
- W1553529648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23507773" @default.
- W1553529648 hasPublicationYear "2013" @default.
- W1553529648 type Work @default.
- W1553529648 sameAs 1553529648 @default.
- W1553529648 citedByCount "174" @default.
- W1553529648 countsByYear W15535296482013 @default.
- W1553529648 countsByYear W15535296482014 @default.
- W1553529648 countsByYear W15535296482015 @default.
- W1553529648 countsByYear W15535296482016 @default.
- W1553529648 countsByYear W15535296482017 @default.
- W1553529648 countsByYear W15535296482018 @default.
- W1553529648 countsByYear W15535296482019 @default.
- W1553529648 countsByYear W15535296482020 @default.
- W1553529648 countsByYear W15535296482021 @default.
- W1553529648 countsByYear W15535296482022 @default.
- W1553529648 countsByYear W15535296482023 @default.
- W1553529648 crossrefType "journal-article" @default.
- W1553529648 hasAuthorship W1553529648A5013988493 @default.
- W1553529648 hasAuthorship W1553529648A5019308143 @default.
- W1553529648 hasAuthorship W1553529648A5023928454 @default.
- W1553529648 hasAuthorship W1553529648A5044893402 @default.
- W1553529648 hasAuthorship W1553529648A5047242201 @default.
- W1553529648 hasAuthorship W1553529648A5051182952 @default.
- W1553529648 hasAuthorship W1553529648A5059786842 @default.
- W1553529648 hasAuthorship W1553529648A5067701288 @default.
- W1553529648 hasAuthorship W1553529648A5071161054 @default.
- W1553529648 hasAuthorship W1553529648A5083841367 @default.
- W1553529648 hasBestOaLocation W15535296482 @default.
- W1553529648 hasConcept C118552586 @default.
- W1553529648 hasConcept C126322002 @default.
- W1553529648 hasConcept C134018914 @default.
- W1553529648 hasConcept C142724271 @default.
- W1553529648 hasConcept C15744967 @default.
- W1553529648 hasConcept C169900460 @default.
- W1553529648 hasConcept C203014093 @default.
- W1553529648 hasConcept C204787440 @default.
- W1553529648 hasConcept C27081682 @default.