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- W1553605380 abstract "Polycystic Ovary-Syndrome (PCOS) is a complex endocrine disorder which affects approximately 5-10% of females of reproductive age (Asuncion et al, 2000, DiamantiKandarakis et al, 1999, Dunaif A, 1997). The syndrome is characterized by abnormal menstrual cyclicity, ovulatory dysfunction, hyperandrogenism and hirsutism (Goodarzi et al, 2011, Hatch et al, 1981). Functional ovarian hyperandrogenism is due to hyperinsulinemia, insulin resistance and hyperlipidemia. The acute problems of the patient, namely ovarian abnormalities and ovulation induction for subfertility, have shifted toward the prevention of long-term health consequences (Cupisti et al, 2007). Insulin resistance is a key feature of females with PCOS, especially, when they are overweight or obese. This has important effects in favouring androgen excess and oligo-anovulation. It is evident, that females with PCOS, especially the overweight ones, have a higher risk for developing type 2 diabetes. It is suggested, that insulin resistance is even more common in overweight patients with PCOS that in lean females. There is a continuum of decrease in insulin sensitivity with increasing abdominal fat accumulation (Zelzer et al, 2011). Hyperandrogenism is associated with fat accumulation at the body trunk. This android, “apple”-like fat pattern is a risk for metabolic disturbances like cardiovascular diseases and type 2 diabetes (Cupisti et al, 2007, Nathan & Moran, 2008)." @default.
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- W1553605380 date "2012-02-24" @default.
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- W1553605380 title "Android Subcutaneous Adipose Tissue Topography in Females with Polycystic Ovary Syndrome: A Visible Phenotype Even in Juveniles" @default.
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- W1553605380 doi "https://doi.org/10.5772/25858" @default.
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