FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553612782> ?p ?o ?g. }

• W1553612782 endingPage "4291" @default.
• W1553612782 startingPage "4283" @default.
• W1553612782 abstract "A progressive, systemic, and low-grade proinflammatory status is one of the major characteristics of immunosenescence. Emerging data suggest a possible contribution of CMV, known to chronically infect a large proportion of humans, lifelong from newborns to centenarians. To test this hypothesis, we evaluated functional T cell responses to two CMV immunogenic proteins, pp65 and IE-1, in 65 chronically infected subjects aged 25-100 years. PBMC were stimulated with mixtures of peptides spanning the entire sequence of both proteins, and Ag specificity and magnitude of intracellular IFN-gamma- and TNF-alpha-positive cells were then analyzed within both CD4+ and CD8+ T cells. Results indicate that pp65 and, to a lesser extent, IE-1 constitute major Ags against which aged people target functionally efficient T cell effector responses with massive production of Th1 cytokines and exhibition of CD107a degranulation marker. As a result, the production of IFN-gamma induced in T cells by both Ags was seven to eight times greater in very old than in young subjects. The comparative analysis of pp65-specific responses in these very long-term carriers revealed a reciprocal relationship between CD4+ and CD8+ producing IFN-gamma in the same individuals. These results indicate that CMV represents an important pathogen responsible for a strong immune activation in human aging. Such a remarkable burden of effector CD4+ and CD8+ T cells may be necessary to protect the elderly from CMV endogenous reactivation, but can turn detrimental by giving a substantial contribution to the proinflammatory status that accompanies the main age-related diseases." @default.
• W1553612782 created "2016-06-24" @default.
• W1553612782 creator A5000553265 @default.
• W1553612782 creator A5001245535 @default.
• W1553612782 creator A5034410072 @default.
• W1553612782 creator A5035496022 @default.
• W1553612782 creator A5043702573 @default.
• W1553612782 creator A5046305152 @default.
• W1553612782 creator A5048745702 @default.
• W1553612782 creator A5050003534 @default.
• W1553612782 creator A5055713485 @default.
• W1553612782 creator A5061211804 @default.
• W1553612782 creator A5076386883 @default.
• W1553612782 creator A5078302741 @default.
• W1553612782 date "2007-09-15" @default.
• W1553612782 modified "2023-09-30" @default.
• W1553612782 title "Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects" @default.
• W1553612782 cites W1533059496 @default.
• W1553612782 cites W1543582555 @default.
• W1553612782 cites W1586815424 @default.
• W1553612782 cites W1603763228 @default.
• W1553612782 cites W1610483123 @default.
• W1553612782 cites W1967684158 @default.
• W1553612782 cites W1971842136 @default.
• W1553612782 cites W1976789091 @default.
• W1553612782 cites W1978632090 @default.
• W1553612782 cites W1983991488 @default.
• W1553612782 cites W1984265860 @default.
• W1553612782 cites W1985093089 @default.
• W1553612782 cites W1985401630 @default.
• W1553612782 cites W1989550920 @default.
• W1553612782 cites W1990826584 @default.
• W1553612782 cites W1991422276 @default.
• W1553612782 cites W1994340919 @default.
• W1553612782 cites W2000119824 @default.
• W1553612782 cites W2002313780 @default.
• W1553612782 cites W2027042725 @default.
• W1553612782 cites W2030414136 @default.
• W1553612782 cites W2030493262 @default.
• W1553612782 cites W2031477951 @default.
• W1553612782 cites W2050020515 @default.
• W1553612782 cites W2050227969 @default.
• W1553612782 cites W2071843907 @default.
• W1553612782 cites W2075774177 @default.
• W1553612782 cites W2081208716 @default.
• W1553612782 cites W2082402714 @default.
• W1553612782 cites W2103059589 @default.
• W1553612782 cites W2103849595 @default.
• W1553612782 cites W2104137724 @default.
• W1553612782 cites W2115180633 @default.
• W1553612782 cites W2115364134 @default.
• W1553612782 cites W2115516753 @default.
• W1553612782 cites W2118613161 @default.
• W1553612782 cites W2120659687 @default.
• W1553612782 cites W2122081259 @default.
• W1553612782 cites W2130510254 @default.
• W1553612782 cites W2143682490 @default.
• W1553612782 cites W2148651797 @default.
• W1553612782 cites W2149204478 @default.
• W1553612782 cites W2153840275 @default.
• W1553612782 cites W2156951291 @default.
• W1553612782 cites W2158993736 @default.
• W1553612782 cites W2163007870 @default.
• W1553612782 cites W2163782912 @default.
• W1553612782 cites W2167842251 @default.
• W1553612782 cites W2168744744 @default.
• W1553612782 doi "https://doi.org/10.4049/jimmunol.179.6.4283" @default.
• W1553612782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17785869" @default.
• W1553612782 hasPublicationYear "2007" @default.
• W1553612782 type Work @default.
• W1553612782 sameAs 1553612782 @default.
• W1553612782 citedByCount "169" @default.
• W1553612782 countsByYear W15536127822012 @default.
• W1553612782 countsByYear W15536127822013 @default.
• W1553612782 countsByYear W15536127822014 @default.
• W1553612782 countsByYear W15536127822015 @default.
• W1553612782 countsByYear W15536127822016 @default.
• W1553612782 countsByYear W15536127822017 @default.
• W1553612782 countsByYear W15536127822018 @default.
• W1553612782 countsByYear W15536127822019 @default.
• W1553612782 countsByYear W15536127822020 @default.
• W1553612782 countsByYear W15536127822021 @default.
• W1553612782 countsByYear W15536127822022 @default.
• W1553612782 countsByYear W15536127822023 @default.
• W1553612782 crossrefType "journal-article" @default.
• W1553612782 hasAuthorship W1553612782A5000553265 @default.
• W1553612782 hasAuthorship W1553612782A5001245535 @default.
• W1553612782 hasAuthorship W1553612782A5034410072 @default.
• W1553612782 hasAuthorship W1553612782A5035496022 @default.
• W1553612782 hasAuthorship W1553612782A5043702573 @default.
• W1553612782 hasAuthorship W1553612782A5046305152 @default.
• W1553612782 hasAuthorship W1553612782A5048745702 @default.
• W1553612782 hasAuthorship W1553612782A5050003534 @default.
• W1553612782 hasAuthorship W1553612782A5055713485 @default.
• W1553612782 hasAuthorship W1553612782A5061211804 @default.
• W1553612782 hasAuthorship W1553612782A5076386883 @default.
• W1553612782 hasAuthorship W1553612782A5078302741 @default.
• W1553612782 hasBestOaLocation W15536127821 @default.

• next