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• W1553649810 startingPage "2701" @default.
• W1553649810 abstract "Myogenic precursor cells known as satellite cells persist in adult skeletal muscle and are responsible for its ability to regenerate after injury. Quiescent satellite cells are activated by signals emanating from damaged muscle. Here we describe the rapid activation of two genes in response to muscle injury; these transcripts encode LPS-inducible CXC chemokine (LIX), a neutrophil chemoattractant, and Tristetraprolin (TTP), an RNA-binding protein implicated in the regulation of cytokine expression. Using a synchronized cell culture model we show that C2C12 myoblasts arrested in G0 exhibit some molecular attributes of satellite cells in vivo: suppression of MyoD and Myf5 expression during G0 and their reactivation in G1. Synchronization also revealed cell cycle dependent expression of CD34, M-cadherin, HGF and PEA3, genes implicated in satellite cell biology. To identify other genes induced in synchronized C2C12 myoblasts we used differential display PCR and isolated LIX and TTP cDNAs. Both LIX and TTP mRNAs are short-lived, encode molecules implicated in inflammation and are transiently induced during growth activation in vitro. Further, LIX and TTP are rapidly induced in response to muscle damage in vivo. TTP expression precedes that of MyoD and is detected 30 minutes after injury. The spatial distribution of LIX and TTP transcripts in injured muscle suggests expression by satellite cells. Our studies suggest that in addition to generating new cells for repair, activated satellite cells may be a source of signaling molecules involved in tissue remodeling during regeneration." @default.
• W1553649810 created "2016-06-24" @default.
• W1553649810 creator A5042746540 @default.
• W1553649810 creator A5046093857 @default.
• W1553649810 creator A5082603706 @default.
• W1553649810 date "2002-07-01" @default.
• W1553649810 modified "2023-09-27" @default.
• W1553649810 title "Tristetraprolin and LPS-inducible CXC chemokine are rapidly induced in presumptive satellite cells in response to skeletal muscle injury" @default.
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• W1553649810 doi "https://doi.org/10.1242/jcs.115.13.2701" @default.
• W1553649810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12077361" @default.
• W1553649810 hasPublicationYear "2002" @default.
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