FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553658214> ?p ?o ?g. }

• W1553658214 endingPage "1531" @default.
• W1553658214 startingPage "1523" @default.
• W1553658214 abstract "Abstract Type 1 diabetes (T1D) is an immune-mediated disease resulting in destruction of insulin-producing pancreatic beta cells. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties, garnering increasing attention as cellular therapy for T1D and other immunologic diseases. However, MSCs generally lack homing molecules, hindering their colonization at inflammatory sites following intravenous (IV) administration. Here, we analyzed whether enforced E-selectin ligand expression on murine MSCs could impact their effect in reversing hyperglycemia in nonobese diabetic (NOD) mice. Although murine MSCs natively do not express the E-selectin-binding determinant sialyl Lewisx (sLex), we found that fucosyltransferase-mediated α(1,3)-exofucosylation of murine MSCs resulted in sLex display uniquely on cell surface CD44 thereby creating hematopoietic cell E-/L-selectin ligand (HCELL), the E-selectin-binding glycoform of CD44. Following IV infusion into diabetic NOD mice, allogeneic HCELL+ MSCs showed threefold greater peri-islet infiltrates compared to buffer-treated (i.e., HCELL−) MSCs, with distribution in proximity to E-selectin-expressing microvessels. Exofucosylation had no effect on MSC immunosuppressive capacity in in vitro assays; however, although engraftment was temporary for both HCELL+ and HCELL− MSCs, administration of HCELL+ MSCs resulted in durable reversal of hyperglycemia, whereas only transient reversal was observed following administration of HCELL− MSCs. Notably, exofucosylation of MSCs generated from CD44−/− mice induced prominent membrane expression of sLex, but IV administration of these MSCs into hyperglycemic NOD mice showed no enhanced pancreatotropism or reversal of hyperglycemia. These findings provide evidence that glycan engineering to enforce HCELL expression boosts trafficking of infused MSCs to pancreatic islets of NOD mice and substantially improves their efficacy in reversing autoimmune diabetes. Stem Cells 2013;33:1523–1531" @default.
• W1553658214 created "2016-06-24" @default.
• W1553658214 creator A5006008204 @default.
• W1553658214 creator A5012402958 @default.
• W1553658214 creator A5023494315 @default.
• W1553658214 creator A5060297602 @default.
• W1553658214 creator A5064373888 @default.
• W1553658214 creator A5089726508 @default.
• W1553658214 date "2015-04-23" @default.
• W1553658214 modified "2023-10-16" @default.
• W1553658214 title "HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice" @default.
• W1553658214 cites W1510928501 @default.
• W1553658214 cites W1978333303 @default.
• W1553658214 cites W1979043688 @default.
• W1553658214 cites W1984033056 @default.
• W1553658214 cites W1985366897 @default.
• W1553658214 cites W1987081782 @default.
• W1553658214 cites W1988885861 @default.
• W1553658214 cites W1990287906 @default.
• W1553658214 cites W1993756804 @default.
• W1553658214 cites W1997470313 @default.
• W1553658214 cites W2001487688 @default.
• W1553658214 cites W2004015037 @default.
• W1553658214 cites W2007104941 @default.
• W1553658214 cites W2026075546 @default.
• W1553658214 cites W2029833407 @default.
• W1553658214 cites W2029959553 @default.
• W1553658214 cites W2035309698 @default.
• W1553658214 cites W2040426333 @default.
• W1553658214 cites W2046620531 @default.
• W1553658214 cites W2052725198 @default.
• W1553658214 cites W2098701890 @default.
• W1553658214 cites W2101995250 @default.
• W1553658214 cites W2113981178 @default.
• W1553658214 cites W2127039646 @default.
• W1553658214 cites W2131755176 @default.
• W1553658214 cites W2139973886 @default.
• W1553658214 cites W2141288873 @default.
• W1553658214 cites W2146830435 @default.
• W1553658214 cites W2158086063 @default.
• W1553658214 cites W2158260035 @default.
• W1553658214 cites W2162512339 @default.
• W1553658214 doi "https://doi.org/10.1002/stem.1948" @default.
• W1553658214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4447299" @default.
• W1553658214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25641589" @default.
• W1553658214 hasPublicationYear "2015" @default.
• W1553658214 type Work @default.
• W1553658214 sameAs 1553658214 @default.
• W1553658214 citedByCount "28" @default.
• W1553658214 countsByYear W15536582142016 @default.
• W1553658214 countsByYear W15536582142017 @default.
• W1553658214 countsByYear W15536582142018 @default.
• W1553658214 countsByYear W15536582142019 @default.
• W1553658214 countsByYear W15536582142020 @default.
• W1553658214 countsByYear W15536582142021 @default.
• W1553658214 countsByYear W15536582142022 @default.
• W1553658214 crossrefType "journal-article" @default.
• W1553658214 hasAuthorship W1553658214A5006008204 @default.
• W1553658214 hasAuthorship W1553658214A5012402958 @default.
• W1553658214 hasAuthorship W1553658214A5023494315 @default.
• W1553658214 hasAuthorship W1553658214A5060297602 @default.
• W1553658214 hasAuthorship W1553658214A5064373888 @default.
• W1553658214 hasAuthorship W1553658214A5089726508 @default.
• W1553658214 hasBestOaLocation W15536582141 @default.
• W1553658214 hasConcept C109159458 @default.
• W1553658214 hasConcept C134018914 @default.
• W1553658214 hasConcept C1491633281 @default.
• W1553658214 hasConcept C151872237 @default.
• W1553658214 hasConcept C18903297 @default.
• W1553658214 hasConcept C198826908 @default.
• W1553658214 hasConcept C203014093 @default.
• W1553658214 hasConcept C2778013207 @default.
• W1553658214 hasConcept C2780130043 @default.
• W1553658214 hasConcept C2780932548 @default.
• W1553658214 hasConcept C28328180 @default.
• W1553658214 hasConcept C502942594 @default.
• W1553658214 hasConcept C55493867 @default.
• W1553658214 hasConcept C555293320 @default.
• W1553658214 hasConcept C55851684 @default.
• W1553658214 hasConcept C86803240 @default.
• W1553658214 hasConcept C8891405 @default.
• W1553658214 hasConcept C95444343 @default.
• W1553658214 hasConceptScore W1553658214C109159458 @default.
• W1553658214 hasConceptScore W1553658214C134018914 @default.
• W1553658214 hasConceptScore W1553658214C1491633281 @default.
• W1553658214 hasConceptScore W1553658214C151872237 @default.
• W1553658214 hasConceptScore W1553658214C18903297 @default.
• W1553658214 hasConceptScore W1553658214C198826908 @default.
• W1553658214 hasConceptScore W1553658214C203014093 @default.
• W1553658214 hasConceptScore W1553658214C2778013207 @default.
• W1553658214 hasConceptScore W1553658214C2780130043 @default.
• W1553658214 hasConceptScore W1553658214C2780932548 @default.
• W1553658214 hasConceptScore W1553658214C28328180 @default.
• W1553658214 hasConceptScore W1553658214C502942594 @default.
• W1553658214 hasConceptScore W1553658214C55493867 @default.
• W1553658214 hasConceptScore W1553658214C555293320 @default.
• W1553658214 hasConceptScore W1553658214C55851684 @default.
• W1553658214 hasConceptScore W1553658214C86803240 @default.

• next