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- W1553671566 abstract "This chapter discusses recent data on the synaptic localization of glutamate receptors and transporters, of glutamate itself, and of glutamine—the major precursor and metabolite of glutamate. Glutamate is the most prevalent excitatory transmitter in the cerebellum and mediates fast transmission in parallel and mossy fiber synapses and probably also in the third major excitatory fiber system formed by the climbing fibers. The operation of a glutamate–glutamine cycle requires that the glial cells be equipped with uptake mechanisms for glutamate. Several glutamate transporters have been cloned in recent years. The organization of key molecules at glutamatergic synapses in the rat cerebellar cortex is analyzed by high resolution immunocytochemical techniques using gold particles as markers. The distinct compartmentation of glutamate and glutamine is consistent with biochemical data indicating an active role of glia in the removal of released glutamate and in the supply of glutamine for de novo synthesis of transmitter glutamate." @default.
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- W1553671566 date "1997-01-01" @default.
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- W1553671566 title "Chapter 6 Molecular organization of cerebellar glutamate synapses" @default.
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- W1553671566 doi "https://doi.org/10.1016/s0079-6123(08)63360-9" @default.
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