FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553674554> ?p ?o ?g. }

• W1553674554 endingPage "270" @default.
• W1553674554 startingPage "185" @default.
• W1553674554 abstract "The fundamental biological process of Ca2+ signaling is known to be important in most eukaryotic cells, and inositol 1,2,5-trisphosphate and ryanodine receptors, intracellular Ca2+ release channels encoded by two distantly related gene families, are central to this phenomenon. Ryanodine receptors in the sarcoplasmic reticulum of skeletal and cardiac muscle have a predominant role in excitation-contraction coupling, but the channels are also present in the endoplasmic reticulum of noncontractile tissues including the central nervous system and the immune system. In all, three highly homologous ryanodine receptor isoforms have been identified, all very large proteins which assemble as (homo)tetramers of ~2 MDa. They contain large cytoplasmically disposed regulatory domains and are always associated with other structural or regulatory proteins, including calmodulin and immunophilins, which can have marked effects on channel function. The type 1 isoform in skeletal muscle is electromechanically coupled to surface membrane voltage sensors, whereas the remaining isoforms appear to be activated solely by endogenous cytoplasmic second messengers or other ligands, including Ca2+ itself (“Ca2+-induced Ca2+ release”). This review concentrates on ryanodine receptor structure-function relationships as probed by a variety of methods and on the molecular mechanisms of channel modulation at the cellular level (including evidence for the regulation of gene expression and transcription). It also touches on the relevance of ryanodine receptors to complex cellular functions and disease." @default.
• W1553674554 created "2016-06-24" @default.
• W1553674554 creator A5000188541 @default.
• W1553674554 creator A5079784209 @default.
• W1553674554 date "1998-01-01" @default.
• W1553674554 modified "2023-10-13" @default.
• W1553674554 title "The Structure, Function, and Cellular Regulation of Ryanodine-Sensitive Ca2+ Release Channels" @default.
• W1553674554 cites W100090922 @default.
• W1553674554 cites W107810048 @default.
• W1553674554 cites W113046133 @default.
• W1553674554 cites W1153613477 @default.
• W1553674554 cites W12635643 @default.
• W1553674554 cites W1483351525 @default.
• W1553674554 cites W1483833346 @default.
• W1553674554 cites W1484907956 @default.
• W1553674554 cites W1490746554 @default.
• W1553674554 cites W1498235130 @default.
• W1553674554 cites W1498369873 @default.
• W1553674554 cites W1500880970 @default.
• W1553674554 cites W1507613750 @default.
• W1553674554 cites W1509451282 @default.
• W1553674554 cites W1509611865 @default.
• W1553674554 cites W1512007810 @default.
• W1553674554 cites W1521810753 @default.
• W1553674554 cites W1522178213 @default.
• W1553674554 cites W1524359813 @default.
• W1553674554 cites W1525891657 @default.
• W1553674554 cites W1525971266 @default.
• W1553674554 cites W1526096964 @default.
• W1553674554 cites W1527086839 @default.
• W1553674554 cites W1529262908 @default.
• W1553674554 cites W1533966875 @default.
• W1553674554 cites W1534636938 @default.
• W1553674554 cites W1538340522 @default.
• W1553674554 cites W1539182280 @default.
• W1553674554 cites W1539661565 @default.
• W1553674554 cites W1540596982 @default.
• W1553674554 cites W1542161436 @default.
• W1553674554 cites W1544132735 @default.
• W1553674554 cites W1547730299 @default.
• W1553674554 cites W1547855890 @default.
• W1553674554 cites W1548506121 @default.
• W1553674554 cites W1549665441 @default.
• W1553674554 cites W1554245708 @default.
• W1553674554 cites W1560226916 @default.
• W1553674554 cites W1560912228 @default.
• W1553674554 cites W1561980328 @default.
• W1553674554 cites W1563253655 @default.
• W1553674554 cites W1563422013 @default.
• W1553674554 cites W1564001098 @default.
• W1553674554 cites W1566622078 @default.
• W1553674554 cites W1567815552 @default.
• W1553674554 cites W1571817303 @default.
• W1553674554 cites W1574047547 @default.
• W1553674554 cites W1586746737 @default.
• W1553674554 cites W1589018486 @default.
• W1553674554 cites W1592405459 @default.
• W1553674554 cites W1592954421 @default.
• W1553674554 cites W1596332074 @default.
• W1553674554 cites W1598081743 @default.
• W1553674554 cites W1600718168 @default.
• W1553674554 cites W1601185542 @default.
• W1553674554 cites W1604648602 @default.
• W1553674554 cites W1607072958 @default.
• W1553674554 cites W1633815641 @default.
• W1553674554 cites W1639940444 @default.
• W1553674554 cites W1640776676 @default.
• W1553674554 cites W1657001864 @default.
• W1553674554 cites W1663036315 @default.
• W1553674554 cites W1696068287 @default.
• W1553674554 cites W1705122500 @default.
• W1553674554 cites W1740533879 @default.
• W1553674554 cites W1792891338 @default.
• W1553674554 cites W1798047275 @default.
• W1553674554 cites W1812043141 @default.
• W1553674554 cites W1820758986 @default.
• W1553674554 cites W1848529608 @default.
• W1553674554 cites W1851168822 @default.
• W1553674554 cites W1857532475 @default.
• W1553674554 cites W1858527956 @default.
• W1553674554 cites W1863795141 @default.
• W1553674554 cites W1870149090 @default.
• W1553674554 cites W1876995878 @default.
• W1553674554 cites W188536477 @default.
• W1553674554 cites W1888518486 @default.
• W1553674554 cites W1890043375 @default.
• W1553674554 cites W1895697393 @default.
• W1553674554 cites W1899501567 @default.
• W1553674554 cites W1933987318 @default.
• W1553674554 cites W1956859188 @default.
• W1553674554 cites W1961148878 @default.
• W1553674554 cites W1963646149 @default.
• W1553674554 cites W1963674209 @default.
• W1553674554 cites W1963851776 @default.
• W1553674554 cites W1963904500 @default.
• W1553674554 cites W1964709412 @default.
• W1553674554 cites W1965083188 @default.
• W1553674554 cites W1965182743 @default.

• next