Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553697733> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1553697733 endingPage "130" @default.
- W1553697733 startingPage "122" @default.
- W1553697733 abstract "Abstract The eta-subunit of the TCR is derived from an alternative splice product of the TCR-zeta gene. The eta-subunit has been extensively characterized in murine T cells, where up to 10% of TCR bear zeta-eta heterodimers rather than zeta-homodimers. In contrast to the significant levels of eta found in murine T cells, in human PBL an eta-like region is expressed spliced to upstream exons of the zeta-gene at no more than 0.25% the level of zeta-mRNA. Analysis of genomic DNA from five additional mammalian species demonstrated that eta-like sequences are highly conserved at a nucleic acid level. The protein sequences encoded in the eta-regions from various species ranged from 28 to 92 amino acids in length, with the first seven deduced amino acids of eta-being common to all species. Within three to five amino acids of this region, all species have five consecutive charged amino acids. Beyond this point, due to translation in different reading frames, there is no significant amino acid homology. The findings of low level of expression of eta-RNA, limited cross-species conservation on a protein level, and the lack of an established functional role for this alternative splice product raise questions as to the potential roles that this subunit may play in TCR function." @default.
- W1553697733 created "2016-06-24" @default.
- W1553697733 creator A5001253371 @default.
- W1553697733 creator A5001493802 @default.
- W1553697733 creator A5011813819 @default.
- W1553697733 creator A5016637617 @default.
- W1553697733 creator A5062915699 @default.
- W1553697733 creator A5083498586 @default.
- W1553697733 date "1993-01-01" @default.
- W1553697733 modified "2023-09-27" @default.
- W1553697733 title "T cell antigen receptor-eta subunit. Low levels of expression and limited cross-species conservation." @default.
- W1553697733 doi "https://doi.org/10.4049/jimmunol.150.1.122" @default.
- W1553697733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8417118" @default.
- W1553697733 hasPublicationYear "1993" @default.
- W1553697733 type Work @default.
- W1553697733 sameAs 1553697733 @default.
- W1553697733 citedByCount "4" @default.
- W1553697733 crossrefType "journal-article" @default.
- W1553697733 hasAuthorship W1553697733A5001253371 @default.
- W1553697733 hasAuthorship W1553697733A5001493802 @default.
- W1553697733 hasAuthorship W1553697733A5011813819 @default.
- W1553697733 hasAuthorship W1553697733A5016637617 @default.
- W1553697733 hasAuthorship W1553697733A5062915699 @default.
- W1553697733 hasAuthorship W1553697733A5083498586 @default.
- W1553697733 hasBestOaLocation W15536977331 @default.
- W1553697733 hasConcept C104292427 @default.
- W1553697733 hasConcept C104317684 @default.
- W1553697733 hasConcept C153911025 @default.
- W1553697733 hasConcept C165525559 @default.
- W1553697733 hasConcept C19317047 @default.
- W1553697733 hasConcept C194583182 @default.
- W1553697733 hasConcept C2776090121 @default.
- W1553697733 hasConcept C36823959 @default.
- W1553697733 hasConcept C515207424 @default.
- W1553697733 hasConcept C54355233 @default.
- W1553697733 hasConcept C86803240 @default.
- W1553697733 hasConcept C8891405 @default.
- W1553697733 hasConceptScore W1553697733C104292427 @default.
- W1553697733 hasConceptScore W1553697733C104317684 @default.
- W1553697733 hasConceptScore W1553697733C153911025 @default.
- W1553697733 hasConceptScore W1553697733C165525559 @default.
- W1553697733 hasConceptScore W1553697733C19317047 @default.
- W1553697733 hasConceptScore W1553697733C194583182 @default.
- W1553697733 hasConceptScore W1553697733C2776090121 @default.
- W1553697733 hasConceptScore W1553697733C36823959 @default.
- W1553697733 hasConceptScore W1553697733C515207424 @default.
- W1553697733 hasConceptScore W1553697733C54355233 @default.
- W1553697733 hasConceptScore W1553697733C86803240 @default.
- W1553697733 hasConceptScore W1553697733C8891405 @default.
- W1553697733 hasIssue "1" @default.
- W1553697733 hasLocation W15536977331 @default.
- W1553697733 hasLocation W15536977332 @default.
- W1553697733 hasOpenAccess W1553697733 @default.
- W1553697733 hasPrimaryLocation W15536977331 @default.
- W1553697733 hasRelatedWork W2025851750 @default.
- W1553697733 hasRelatedWork W2035381332 @default.
- W1553697733 hasRelatedWork W2044900269 @default.
- W1553697733 hasRelatedWork W2046690258 @default.
- W1553697733 hasRelatedWork W2085975240 @default.
- W1553697733 hasRelatedWork W2113067903 @default.
- W1553697733 hasRelatedWork W2119764327 @default.
- W1553697733 hasRelatedWork W2139592023 @default.
- W1553697733 hasRelatedWork W2168467210 @default.
- W1553697733 hasRelatedWork W2376046968 @default.
- W1553697733 hasVolume "150" @default.
- W1553697733 isParatext "false" @default.
- W1553697733 isRetracted "false" @default.
- W1553697733 magId "1553697733" @default.
- W1553697733 workType "article" @default.