FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553759318> ?p ?o ?g. }

• W1553759318 endingPage "1302" @default.
• W1553759318 startingPage "1294" @default.
• W1553759318 abstract "Mammalian synaptotagmins constitute a multigene family of at least 11 membrane proteins. We have characterized synaptotagmin IV using antibodies directed against the C2A domain of the protein. Antibodies reacted specifically with a protein band that migrated as a 41-44 kDa doublet. Synaptotagmin IV expression was regulated throughout development. A strong decrease in the amount detected by Western blotting occurred between postnatal day 5 and adulthood, in agreement with studies on the expression of synaptotagmin IV transcripts. In subcellular fractionation, synaptotagmin IV was not detected in the synaptic vesicle-enriched fraction. Immunofluorescence microscopy was concordant with this finding. In 6-day-old rat cerebellum and cultured hippocampal neurons the subcellular distribution of synaptotagmin IV was clearly different from that of synaptotagmin I. Synaptotagmin IV displayed a punctate non-polarized distribution on neuronal extensions, whereas synaptotagmin I staining was essentially synaptic. Synaptotagmin IV staining was also observed in the soma in strong perinuclear fluorescent puncta superimposed on that of Golgi/TGN markers. Furthermore, synaptotagmin IV was seen in the proximal part of the growth cone domain and not in the microfilament-rich region which includes filopodia. Co-localizations with the adhesion molecules vinculin and zyxin at the proximal part of growth cones were observed. Synaptotagmin IV may thus be involved in the regulation of specific membrane-trafficking pathways during brain development." @default.
• W1553759318 created "2016-06-24" @default.
• W1553759318 creator A5006129467 @default.
• W1553759318 creator A5015247110 @default.
• W1553759318 creator A5058994481 @default.
• W1553759318 creator A5059202934 @default.
• W1553759318 creator A5067246434 @default.
• W1553759318 creator A5069451600 @default.
• W1553759318 creator A5086403606 @default.
• W1553759318 creator A5087874511 @default.
• W1553759318 date "2000-04-01" @default.
• W1553759318 modified "2023-09-30" @default.
• W1553759318 title "Synaptotagmin I and IV define distinct populations of neuronal transport vesicles" @default.
• W1553759318 cites W1584917605 @default.
• W1553759318 cites W1947397418 @default.
• W1553759318 cites W1970930136 @default.
• W1553759318 cites W1971016259 @default.
• W1553759318 cites W1981913205 @default.
• W1553759318 cites W1985512071 @default.
• W1553759318 cites W1988691994 @default.
• W1553759318 cites W1989721214 @default.
• W1553759318 cites W1990911867 @default.
• W1553759318 cites W1993304062 @default.
• W1553759318 cites W1993518080 @default.
• W1553759318 cites W1996862455 @default.
• W1553759318 cites W2008163056 @default.
• W1553759318 cites W2018757497 @default.
• W1553759318 cites W2020300164 @default.
• W1553759318 cites W2033520740 @default.
• W1553759318 cites W2041675958 @default.
• W1553759318 cites W2061272721 @default.
• W1553759318 cites W2071678827 @default.
• W1553759318 cites W2076636373 @default.
• W1553759318 cites W2089913650 @default.
• W1553759318 cites W2092562744 @default.
• W1553759318 cites W2096721619 @default.
• W1553759318 cites W2120577107 @default.
• W1553759318 cites W2136422440 @default.
• W1553759318 cites W2151766851 @default.
• W1553759318 cites W2154472809 @default.
• W1553759318 cites W2184631394 @default.
• W1553759318 cites W4300750028 @default.
• W1553759318 doi "https://doi.org/10.1046/j.1460-9568.2000.00013.x" @default.
• W1553759318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10762358" @default.
• W1553759318 hasPublicationYear "2000" @default.
• W1553759318 type Work @default.
• W1553759318 sameAs 1553759318 @default.
• W1553759318 citedByCount "44" @default.
• W1553759318 countsByYear W15537593182012 @default.
• W1553759318 countsByYear W15537593182014 @default.
• W1553759318 countsByYear W15537593182015 @default.
• W1553759318 countsByYear W15537593182018 @default.
• W1553759318 countsByYear W15537593182020 @default.
• W1553759318 crossrefType "journal-article" @default.
• W1553759318 hasAuthorship W1553759318A5006129467 @default.
• W1553759318 hasAuthorship W1553759318A5015247110 @default.
• W1553759318 hasAuthorship W1553759318A5058994481 @default.
• W1553759318 hasAuthorship W1553759318A5059202934 @default.
• W1553759318 hasAuthorship W1553759318A5067246434 @default.
• W1553759318 hasAuthorship W1553759318A5069451600 @default.
• W1553759318 hasAuthorship W1553759318A5086403606 @default.
• W1553759318 hasAuthorship W1553759318A5087874511 @default.
• W1553759318 hasConcept C130316041 @default.
• W1553759318 hasConcept C148785051 @default.
• W1553759318 hasConcept C185592680 @default.
• W1553759318 hasConcept C203014093 @default.
• W1553759318 hasConcept C204232928 @default.
• W1553759318 hasConcept C2777209535 @default.
• W1553759318 hasConcept C2909695770 @default.
• W1553759318 hasConcept C41625074 @default.
• W1553759318 hasConcept C50493954 @default.
• W1553759318 hasConcept C55493867 @default.
• W1553759318 hasConcept C86473631 @default.
• W1553759318 hasConcept C86803240 @default.
• W1553759318 hasConcept C95444343 @default.
• W1553759318 hasConceptScore W1553759318C130316041 @default.
• W1553759318 hasConceptScore W1553759318C148785051 @default.
• W1553759318 hasConceptScore W1553759318C185592680 @default.
• W1553759318 hasConceptScore W1553759318C203014093 @default.
• W1553759318 hasConceptScore W1553759318C204232928 @default.
• W1553759318 hasConceptScore W1553759318C2777209535 @default.
• W1553759318 hasConceptScore W1553759318C2909695770 @default.
• W1553759318 hasConceptScore W1553759318C41625074 @default.
• W1553759318 hasConceptScore W1553759318C50493954 @default.
• W1553759318 hasConceptScore W1553759318C55493867 @default.
• W1553759318 hasConceptScore W1553759318C86473631 @default.
• W1553759318 hasConceptScore W1553759318C86803240 @default.
• W1553759318 hasConceptScore W1553759318C95444343 @default.
• W1553759318 hasIssue "4" @default.
• W1553759318 hasLocation W15537593181 @default.
• W1553759318 hasLocation W15537593182 @default.
• W1553759318 hasOpenAccess W1553759318 @default.
• W1553759318 hasPrimaryLocation W15537593181 @default.
• W1553759318 hasRelatedWork W1553759318 @default.
• W1553759318 hasRelatedWork W1966726500 @default.
• W1553759318 hasRelatedWork W1971497129 @default.
• W1553759318 hasRelatedWork W1988954096 @default.
• W1553759318 hasRelatedWork W2027860308 @default.

• next