FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553771325> ?p ?o ?g. }

• W1553771325 abstract "The most rigorous scenario for testing a candidate rheumatoid arthritis therapeutic would be to use clinically relevant biomarkers and readouts to monitor disease development in an animal model that has a mechanism of disease that reflects the human condition. Treatment should begin when the full spectrum of arthritic processes, including bone damage, is present. We have tried to take this approach to evaluate a novel EP4 receptor antagonist (ER-886046) for its anti-arthritic potential. This work aimed not only to test a potential drug, but to also demonstrate a strategy for performing a more clinically relevant evaluation of future candidate arthritis treatments. A variety of biomarkers including: radiographic evaluation, clinical scoring, histology analysis, F4/80 macrophage immunohistochemistry, luminol bioluminescent imaging and (99m)Tc-MDP-SPECT imaging were evaluated as disease readouts in the mouse anti-collagen antibody induced arthritis model (CAIA). CAIA mice were treated either prophylactically or therapeutically with ER-886046 and the compound's efficacy was probed using the various biomarkers and compared to the reference drugs prednisolone and celecoxib. The various biomarkers effectively measured different aspects of arthritis pathology and consistently demonstrated the efficacy of ER-886046. The compound was found to be effective even when dosed therapeutically after bone damaging processes had initiated. The results presented herein demonstrate how biomarkers and a clinically relevant experimental design can be used to evaluate a candidate therapeutic. Utilization of clinically relevant biomarkers may provide a means for more translatable pre-clinical testing of candidate therapeutics and may provide information on their mechanism of action." @default.
• W1553771325 created "2016-06-24" @default.
• W1553771325 creator A5037761513 @default.
• W1553771325 creator A5047291870 @default.
• W1553771325 creator A5051980063 @default.
• W1553771325 creator A5064826717 @default.
• W1553771325 creator A5065412642 @default.
• W1553771325 creator A5068290128 @default.
• W1553771325 creator A5073229696 @default.
• W1553771325 creator A5073697486 @default.
• W1553771325 creator A5081486669 @default.
• W1553771325 creator A5085444021 @default.
• W1553771325 creator A5085586770 @default.
• W1553771325 creator A5089575625 @default.
• W1553771325 date "2013-01-01" @default.
• W1553771325 modified "2023-10-12" @default.
• W1553771325 title "Evaluation of a candidate anti-arthritic drug using the mouse collagen antibody induced arthritis model and clinically relevant biomarkers." @default.
• W1553771325 cites W1542422583 @default.
• W1553771325 cites W1567785785 @default.
• W1553771325 cites W1978480471 @default.
• W1553771325 cites W1983754832 @default.
• W1553771325 cites W1991238781 @default.
• W1553771325 cites W1998749895 @default.
• W1553771325 cites W2042342193 @default.
• W1553771325 cites W2043827616 @default.
• W1553771325 cites W2048360841 @default.
• W1553771325 cites W2086075223 @default.
• W1553771325 cites W2101460836 @default.
• W1553771325 cites W2103567384 @default.
• W1553771325 cites W2106070528 @default.
• W1553771325 cites W2123580807 @default.
• W1553771325 cites W2132981126 @default.
• W1553771325 cites W2142924005 @default.
• W1553771325 cites W2157648093 @default.
• W1553771325 cites W2170427936 @default.
• W1553771325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560477" @default.
• W1553771325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23390569" @default.
• W1553771325 hasPublicationYear "2013" @default.
• W1553771325 type Work @default.
• W1553771325 sameAs 1553771325 @default.
• W1553771325 citedByCount "10" @default.
• W1553771325 countsByYear W15537713252014 @default.
• W1553771325 countsByYear W15537713252015 @default.
• W1553771325 countsByYear W15537713252016 @default.
• W1553771325 countsByYear W15537713252017 @default.
• W1553771325 countsByYear W15537713252018 @default.
• W1553771325 crossrefType "journal-article" @default.
• W1553771325 hasAuthorship W1553771325A5037761513 @default.
• W1553771325 hasAuthorship W1553771325A5047291870 @default.
• W1553771325 hasAuthorship W1553771325A5051980063 @default.
• W1553771325 hasAuthorship W1553771325A5064826717 @default.
• W1553771325 hasAuthorship W1553771325A5065412642 @default.
• W1553771325 hasAuthorship W1553771325A5068290128 @default.
• W1553771325 hasAuthorship W1553771325A5073229696 @default.
• W1553771325 hasAuthorship W1553771325A5073697486 @default.
• W1553771325 hasAuthorship W1553771325A5081486669 @default.
• W1553771325 hasAuthorship W1553771325A5085444021 @default.
• W1553771325 hasAuthorship W1553771325A5085586770 @default.
• W1553771325 hasAuthorship W1553771325A5089575625 @default.
• W1553771325 hasConcept C142724271 @default.
• W1553771325 hasConcept C203014093 @default.
• W1553771325 hasConcept C2776467144 @default.
• W1553771325 hasConcept C2777077863 @default.
• W1553771325 hasConcept C2777575956 @default.
• W1553771325 hasConcept C2780035454 @default.
• W1553771325 hasConcept C64903051 @default.
• W1553771325 hasConcept C71924100 @default.
• W1553771325 hasConcept C98274493 @default.
• W1553771325 hasConceptScore W1553771325C142724271 @default.
• W1553771325 hasConceptScore W1553771325C203014093 @default.
• W1553771325 hasConceptScore W1553771325C2776467144 @default.
• W1553771325 hasConceptScore W1553771325C2777077863 @default.
• W1553771325 hasConceptScore W1553771325C2777575956 @default.
• W1553771325 hasConceptScore W1553771325C2780035454 @default.
• W1553771325 hasConceptScore W1553771325C64903051 @default.
• W1553771325 hasConceptScore W1553771325C71924100 @default.
• W1553771325 hasConceptScore W1553771325C98274493 @default.
• W1553771325 hasLocation W15537713251 @default.
• W1553771325 hasOpenAccess W1553771325 @default.
• W1553771325 hasPrimaryLocation W15537713251 @default.
• W1553771325 hasRelatedWork W1964055205 @default.
• W1553771325 hasRelatedWork W2023469280 @default.
• W1553771325 hasRelatedWork W2062770015 @default.
• W1553771325 hasRelatedWork W2123204436 @default.
• W1553771325 hasRelatedWork W2132041924 @default.
• W1553771325 hasRelatedWork W2146808843 @default.
• W1553771325 hasRelatedWork W2159560982 @default.
• W1553771325 hasRelatedWork W2263518146 @default.
• W1553771325 hasRelatedWork W2465992342 @default.
• W1553771325 hasRelatedWork W2750054974 @default.
• W1553771325 hasRelatedWork W2769588922 @default.
• W1553771325 hasRelatedWork W3128936301 @default.
• W1553771325 hasRelatedWork W3198606434 @default.
• W1553771325 hasRelatedWork W1001691605 @default.
• W1553771325 hasRelatedWork W1850604191 @default.
• W1553771325 hasRelatedWork W2220951471 @default.
• W1553771325 hasRelatedWork W2230431997 @default.
• W1553771325 hasRelatedWork W2550984721 @default.
• W1553771325 hasRelatedWork W2788092320 @default.
• W1553771325 hasRelatedWork W2824383203 @default.

• next