FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553821274> ?p ?o ?g. }

• W1553821274 endingPage "1137" @default.
• W1553821274 startingPage "1123" @default.
• W1553821274 abstract "Previously, we identified and established the antigenicity of 17 CD8+ T cell epitopes from five P. falciparum Ags that are restricted by multiple common HLA class I alleles. Here, we report the identification of 11 peptides from the same Ags, cicumsporozoite protein, sporozoite surface protein 2, exported protein-1, and liver-stage Ag-1, that bind between at least five and up to 11 different HLA-DR molecules representative of the most common HLA-DR Ags worldwide. These peptides recall lymphoproliferative and cytokine responses in immune individuals experimentally immunized with radiation-attenuated Plasmodium falciparum sporozoites (irradiated sporozoites) or semi-immune individuals naturally exposed to malaria in Irian Jaya or Kenya. We establish that all peptides are recognized by individuals of each of the three populations, and that the frequency and magnitude of helper T lymphocyte responses to each peptide is influenced by the intensity of exposure to P. falciparum sporozoites. Mean frequencies of lymphoproliferative responses are 53.2% (irradiated sporozoites) vs 22.4% (Kenyan) vs 5.8% (Javanese), and mean frequencies of IFN-gamma responses are 66.3% (irradiated sporozoites) vs 27.3% (Kenyan) vs 8. 7% (Javanese). The identification of HLA class II degenerate T cell epitopes from P. falciparum validates our predictive strategy in a biologically relevant system and supports the potential for developing a broadly efficacious epitope-based vaccine against malaria focused on a limited number of peptide specificities." @default.
• W1553821274 created "2016-06-24" @default.
• W1553821274 creator A5000295555 @default.
• W1553821274 creator A5006691721 @default.
• W1553821274 creator A5010966529 @default.
• W1553821274 creator A5036354240 @default.
• W1553821274 creator A5037285448 @default.
• W1553821274 creator A5041720192 @default.
• W1553821274 creator A5043039016 @default.
• W1553821274 creator A5044411943 @default.
• W1553821274 creator A5045023447 @default.
• W1553821274 creator A5057248986 @default.
• W1553821274 creator A5062001150 @default.
• W1553821274 creator A5065477615 @default.
• W1553821274 creator A5087303099 @default.
• W1553821274 creator A5090174108 @default.
• W1553821274 date "2000-07-15" @default.
• W1553821274 modified "2023-10-13" @default.
• W1553821274 title "HLA-DR-Promiscuous T Cell Epitopes from<i>Plasmodium</i> <i>falciparum</i>Pre-Erythrocytic-Stage Antigens Restricted by Multiple HLA Class II Alleles" @default.
• W1553821274 cites W1503151765 @default.
• W1553821274 cites W1540975618 @default.
• W1553821274 cites W1557300036 @default.
• W1553821274 cites W1560653090 @default.
• W1553821274 cites W1576765906 @default.
• W1553821274 cites W1589719720 @default.
• W1553821274 cites W1593739464 @default.
• W1553821274 cites W1675195038 @default.
• W1553821274 cites W176624560 @default.
• W1553821274 cites W189869399 @default.
• W1553821274 cites W1944657476 @default.
• W1553821274 cites W1956798988 @default.
• W1553821274 cites W1963710292 @default.
• W1553821274 cites W1965485518 @default.
• W1553821274 cites W1967748798 @default.
• W1553821274 cites W1969057879 @default.
• W1553821274 cites W1976328578 @default.
• W1553821274 cites W1980752431 @default.
• W1553821274 cites W1983954483 @default.
• W1553821274 cites W2004000958 @default.
• W1553821274 cites W2004070715 @default.
• W1553821274 cites W2026223457 @default.
• W1553821274 cites W2026893977 @default.
• W1553821274 cites W2028265413 @default.
• W1553821274 cites W2041553413 @default.
• W1553821274 cites W2052321000 @default.
• W1553821274 cites W2053408779 @default.
• W1553821274 cites W2059274025 @default.
• W1553821274 cites W2062032776 @default.
• W1553821274 cites W2065795429 @default.
• W1553821274 cites W2066729340 @default.
• W1553821274 cites W2066905955 @default.
• W1553821274 cites W2070457810 @default.
• W1553821274 cites W2072621353 @default.
• W1553821274 cites W2073254456 @default.
• W1553821274 cites W2073350315 @default.
• W1553821274 cites W2073557509 @default.
• W1553821274 cites W2080980504 @default.
• W1553821274 cites W2094600996 @default.
• W1553821274 cites W2100667751 @default.
• W1553821274 cites W2102664616 @default.
• W1553821274 cites W2123115709 @default.
• W1553821274 cites W2123545365 @default.
• W1553821274 cites W2137940095 @default.
• W1553821274 cites W2156608151 @default.
• W1553821274 cites W2156888022 @default.
• W1553821274 cites W2159404298 @default.
• W1553821274 cites W2238131148 @default.
• W1553821274 cites W2395533360 @default.
• W1553821274 cites W2431527453 @default.
• W1553821274 cites W304288403 @default.
• W1553821274 cites W4300007004 @default.
• W1553821274 cites W4365411595 @default.
• W1553821274 doi "https://doi.org/10.4049/jimmunol.165.2.1123" @default.
• W1553821274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10878392" @default.
• W1553821274 hasPublicationYear "2000" @default.
• W1553821274 type Work @default.
• W1553821274 sameAs 1553821274 @default.
• W1553821274 citedByCount "129" @default.
• W1553821274 countsByYear W15538212742012 @default.
• W1553821274 countsByYear W15538212742013 @default.
• W1553821274 countsByYear W15538212742014 @default.
• W1553821274 countsByYear W15538212742015 @default.
• W1553821274 countsByYear W15538212742016 @default.
• W1553821274 countsByYear W15538212742017 @default.
• W1553821274 countsByYear W15538212742018 @default.
• W1553821274 countsByYear W15538212742019 @default.
• W1553821274 countsByYear W15538212742020 @default.
• W1553821274 countsByYear W15538212742021 @default.
• W1553821274 countsByYear W15538212742022 @default.
• W1553821274 countsByYear W15538212742023 @default.
• W1553821274 crossrefType "journal-article" @default.
• W1553821274 hasAuthorship W1553821274A5000295555 @default.
• W1553821274 hasAuthorship W1553821274A5006691721 @default.
• W1553821274 hasAuthorship W1553821274A5010966529 @default.
• W1553821274 hasAuthorship W1553821274A5036354240 @default.
• W1553821274 hasAuthorship W1553821274A5037285448 @default.
• W1553821274 hasAuthorship W1553821274A5041720192 @default.
• W1553821274 hasAuthorship W1553821274A5043039016 @default.

• next