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• W1553846656 abstract "To cite this article: Singh AK, Stock P, Akbari O. Role of PD-L1 and PD-L2 in allergic diseases and asthma. Allergy 2011; 66: 155–162. Abstract Asthma is the result of chronic airway inflammation associated predominantly with CD4+ cells, eosinophils, mast cells, and basophils. Several T-cells subsets, including NKT cells, play a critical role in orchestrating the inflammation in the airways predominantly, by secreting interleukin-4 and interleukin-13. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was shown to regulate T-cell activation and tolerance. PD-1 has been characterized as a negative regulator of conventional CD4+T cells. In addition, the relative roles of PD-L1 and PD-L2 in regulating the activation and function of T cells have recently been characterized. Recent studies have demonstrated that PD-L1 and PD-L2 have important but opposing roles in modulating and polarizing T-cell functions in airway hyperreactivity. Whereas the severity of asthma is greatly enhanced in absence of PD-L2, PD-L1 deficiency resulted in reduced airway hyperresponsiveness and only minimal inflammation. This observation is partially because of the polarization of NKT cells in PD-L1- and PD-L2-deficient mice. This review will discuss the recent literature regarding the role of PD-L1 and PD-L2 in allergic disease and asthma. Current understanding of the role of PD ligands in allergic asthma gives impetus to the development of novel therapeutic approaches." @default.
• W1553846656 created "2016-06-24" @default.
• W1553846656 creator A5017373103 @default.
• W1553846656 creator A5027660549 @default.
• W1553846656 creator A5060198895 @default.
• W1553846656 date "2010-08-17" @default.
• W1553846656 modified "2023-10-12" @default.
• W1553846656 title "Role of PD-L1 and PD-L2 in allergic diseases and asthma" @default.
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• W1553846656 doi "https://doi.org/10.1111/j.1398-9995.2010.02458.x" @default.
• W1553846656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3017219" @default.
• W1553846656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20722638" @default.
• W1553846656 hasPublicationYear "2010" @default.
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