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- W155385334 endingPage "147" @default.
- W155385334 startingPage "91" @default.
- W155385334 abstract "This chapter discusses the biological properties of Bacillus Calmette Guérin (BCG) that are thought to have potential in stimulating host responses to malignant cells. BCG is a highly complex organism that provokes many types of host response. The chapter also describes the current status of their evaluation in experimental animal systems. Immunotherapy is the treatment of human malignant disease. This approach indicates that immunity can be induced against syngeneic transplants of experimental animal tumors, particularly those induced by chemical carcinogens and oncogenic viruses. The mechanisms of tumor rejection mediated by immune responses to tumor-associated antigens in well-defined animal systems are still inadequately understood. Due to these uncertainties, most clinical trials have adopted empirical approaches utilizing bacterial adjuvants to stimulate in a specific or a nonspecific fashion host responses to the tumor. BCG has been widely used in these approaches because of its known adjuvanticity. The chapter concludes with several guidelines along which investigation into tumor therapy could be directed." @default.
- W155385334 created "2016-06-24" @default.
- W155385334 creator A5010003559 @default.
- W155385334 creator A5076865440 @default.
- W155385334 date "1978-01-01" @default.
- W155385334 modified "2023-09-29" @default.
- W155385334 title "Bcg in Tumor Immunotherapy" @default.
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