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• W1553897055 endingPage "1660" @default.
• W1553897055 startingPage "1652" @default.
• W1553897055 abstract "BACKGROUND AND PURPOSE The endocannabinoid system appears to play a pivotal role in mediating the rewarding and reinforcing effects of nicotine. Recent studies have shown that the inhibition of fatty acid amide hydrolase (FAAH) attenuates reinstatement of nicotine‐seeking induced by nicotine priming and nicotine‐associated cues. FAAH hydrolyses the endogenous endocannabinoid anandamide, as well as other non‐cannabinoid ligands such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). As OEA and PEA can attenuate both nicotine‐taking and nicotine‐seeking behaviour, the specific role of anandamide remains unclear. In this study, we have tested the selective anadamide uptake inhibitor, VDM11, which elevates anandamide levels without affecting levels of OEA/PEA, on nicotine‐taking and nicotine‐seeking behaviour. EXPERIMENTAL APPROACH We used a nicotine intravenous self‐administration model in rats to assess the effect of VDM11, given i.p., on nicotine taking using fixed and progressive ratio schedules of reinforcement as well as on reinstatement of nicotine‐seeking induced by nicotine priming and nicotine‐associated cues. KEY RESULTS VDM11 did not affect levels of responding for nicotine under fixed‐ratio and progressive‐ratio schedules of reinforcement. In contrast, VDM11 dose‐dependently attenuated reinstatement of nicotine‐seeking behaviour induced by nicotine‐associated cues and nicotine priming. CONCLUSIONS AND IMPLICATIONS These results indicate that ligands elevating anandamide levels could have therapeutic value for preventing relapse into nicotine‐seeking behaviour and should be tested in humans trying to quit smoking." @default.
• W1553897055 created "2016-06-24" @default.
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• W1553897055 date "2011-10-24" @default.
• W1553897055 modified "2023-10-18" @default.
• W1553897055 title "The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake" @default.
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• W1553897055 doi "https://doi.org/10.1111/j.1476-5381.2011.01440.x" @default.
• W1553897055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3230812" @default.
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