Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553899097> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- W1553899097 endingPage "145" @default.
- W1553899097 startingPage "142" @default.
- W1553899097 abstract "目的建立适于在线自动化制备多巴胺转运蛋白显像剂^11C-甲基-N-2β-甲基酯-3β-(4-氟-苯基)托烷(β-CFT)的方法。方法将“C-碘代甲烷转换成“C-三氟甲基磺酰甲烷(Triflate-甲烷)，与前体2β-甲基酯-3β-(4-氟-苯基)去甲基托烷(nor-β-CFF)反应，在线转移到反相C-18柱上纯化，最后将^11C-β-CFT洗脱于收集瓶。正常大鼠给药后不同时间处死，测定其生物分布。2例帕金森病(PD)患者分别用^11C-β-CFT和多巴胺D2受体显像剂^11C-雷氯必利(Raclopride)显像。结果在线自动化制备的^11C-β-CFT放化纯>98％，比活度>2TBq／mmol，校正合成效率为(92．4±3．1)％，从^11C-碘代甲烷到^11C-β-CET的合成时间为4min。放射性在正常大鼠体内主要分布于肝、肾和脑；颅内纹状体摄取放射性最高，与小脑的比值在5、15、30min分别为2．15、4．18和3．15。2例PD患者显像结果表明，^11C-β-CFT对PD的诊断比^11C-Raclopride灵敏。结论在线自动化制备^11C-β-CFT效率高，速度快，放化纯高。初步显像结果表明，其可满足临床需要。" @default.
- W1553899097 created "2016-06-24" @default.
- W1553899097 creator A5017158222 @default.
- W1553899097 creator A5021306583 @default.
- W1553899097 creator A5065308024 @default.
- W1553899097 creator A5068896980 @default.
- W1553899097 creator A5070573358 @default.
- W1553899097 creator A5082957497 @default.
- W1553899097 creator A5088463881 @default.
- W1553899097 date "2005-06-25" @default.
- W1553899097 modified "2023-10-18" @default.
- W1553899097 title "在线自动化制备多巴胺转运蛋白显像剂^11C-β-CFT" @default.
- W1553899097 hasPublicationYear "2005" @default.
- W1553899097 type Work @default.
- W1553899097 sameAs 1553899097 @default.
- W1553899097 citedByCount "0" @default.
- W1553899097 crossrefType "journal-article" @default.
- W1553899097 hasAuthorship W1553899097A5017158222 @default.
- W1553899097 hasAuthorship W1553899097A5021306583 @default.
- W1553899097 hasAuthorship W1553899097A5065308024 @default.
- W1553899097 hasAuthorship W1553899097A5068896980 @default.
- W1553899097 hasAuthorship W1553899097A5070573358 @default.
- W1553899097 hasAuthorship W1553899097A5082957497 @default.
- W1553899097 hasAuthorship W1553899097A5088463881 @default.
- W1553899097 hasConcept C127313418 @default.
- W1553899097 hasConcept C185592680 @default.
- W1553899097 hasConcept C2989005 @default.
- W1553899097 hasConcept C71924100 @default.
- W1553899097 hasConceptScore W1553899097C127313418 @default.
- W1553899097 hasConceptScore W1553899097C185592680 @default.
- W1553899097 hasConceptScore W1553899097C2989005 @default.
- W1553899097 hasConceptScore W1553899097C71924100 @default.
- W1553899097 hasIssue "03" @default.
- W1553899097 hasLocation W15538990971 @default.
- W1553899097 hasOpenAccess W1553899097 @default.
- W1553899097 hasPrimaryLocation W15538990971 @default.
- W1553899097 hasVolume "25" @default.
- W1553899097 isParatext "false" @default.
- W1553899097 isRetracted "false" @default.
- W1553899097 magId "1553899097" @default.
- W1553899097 workType "article" @default.