FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553913360> ?p ?o ?g. }

• W1553913360 endingPage "6840" @default.
• W1553913360 startingPage "6834" @default.
• W1553913360 abstract "Bis(monoacylglycero)phosphate (BMP) has the unique stereoconfiguration of 3-acyl-sn-glycero-1-phosphoryl-1'-sn-[3'-acylglycerol] (Brotherus, J., Renkonen, O., Herrmann, J., and Fischer, W. (1974) Chem. Phys. Lipids 13, 178-182) which differs from other known mammalian phospholipids that have the sn-glycero-3-phosphoryl configuration. This stereochemistry may contribute to its physiologic function. Here we describe studies using the macrophage-like cell line RAW 264.7 designed to determined how this unique stereoconfiguration occurs. These studies show that the stereoconfiguration of BMP produced from exogenous phosphatidylglycerol (PG) by RAW 264.7 cells has the expected stereoconfiguration of 3-acyl-sn-glycero-1-phosphoryl-1'-sn-[3'-acylglycerol]. Experiments using diacyl-sn-[2-3H]glycero-3-phosphoryl-sn-1'-[2-3H]glycerol demonstrate that this unique stereoconfiguration is not produced due to an oxidation/reduction mechanism involving the sn-2-glycerol carbon. When dioleoyl-sn-[1-14C]glycero-3-phosphoryl-rac-glycerol was converted to 14C-labeled BMP, the 14C label was found esterified to the phosphate moiety. These results suggest that a stereospecific enzyme is capable of reorienting the radiolabeled glycerol backbone of this PG substrate, effectively changing the stereochemistry of the lipid. We also show that this enzyme is stereoselective with regard to the base glycerol moiety of the substrate PG used. Finally, we propose a new pathway for the synthesis of BMP from PG." @default.
• W1553913360 created "2016-06-24" @default.
• W1553913360 creator A5007333586 @default.
• W1553913360 creator A5062792890 @default.
• W1553913360 creator A5078434024 @default.
• W1553913360 creator A5082820216 @default.
• W1553913360 creator A5085731615 @default.
• W1553913360 date "1991-04-01" @default.
• W1553913360 modified "2023-10-17" @default.
• W1553913360 title "Glycerol reorientation during the conversion of phosphatidylglycerol to bis(monoacylglycerol)phosphate in macrophage-like RAW 264.7 cells." @default.
• W1553913360 cites W132062982 @default.
• W1553913360 cites W1486946238 @default.
• W1553913360 cites W1495900571 @default.
• W1553913360 cites W1522146362 @default.
• W1553913360 cites W1530081524 @default.
• W1553913360 cites W1537579819 @default.
• W1553913360 cites W1591571853 @default.
• W1553913360 cites W1768606565 @default.
• W1553913360 cites W1805440445 @default.
• W1553913360 cites W1964834204 @default.
• W1553913360 cites W1983600681 @default.
• W1553913360 cites W1989581601 @default.
• W1553913360 cites W1994887026 @default.
• W1553913360 cites W2004516442 @default.
• W1553913360 cites W2007876616 @default.
• W1553913360 cites W2013140908 @default.
• W1553913360 cites W2017501541 @default.
• W1553913360 cites W2020823395 @default.
• W1553913360 cites W2024603782 @default.
• W1553913360 cites W2031891946 @default.
• W1553913360 cites W2037872508 @default.
• W1553913360 cites W2047875059 @default.
• W1553913360 cites W2048192611 @default.
• W1553913360 cites W2058557381 @default.
• W1553913360 cites W2067456310 @default.
• W1553913360 cites W2071877745 @default.
• W1553913360 cites W2080637379 @default.
• W1553913360 cites W2081167372 @default.
• W1553913360 cites W2083915268 @default.
• W1553913360 cites W2085188917 @default.
• W1553913360 cites W2092104041 @default.
• W1553913360 cites W2093332597 @default.
• W1553913360 cites W2096650460 @default.
• W1553913360 cites W2152311269 @default.
• W1553913360 cites W2182068573 @default.
• W1553913360 cites W2182662710 @default.
• W1553913360 cites W2185868958 @default.
• W1553913360 cites W2188811294 @default.
• W1553913360 cites W2313357044 @default.
• W1553913360 cites W2414820635 @default.
• W1553913360 cites W2417542675 @default.
• W1553913360 cites W2993550500 @default.
• W1553913360 cites W4214603423 @default.
• W1553913360 cites W4241319799 @default.
• W1553913360 cites W4250038822 @default.
• W1553913360 cites W89455282 @default.
• W1553913360 doi "https://doi.org/10.1016/s0021-9258(20)89576-3" @default.
• W1553913360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2016299" @default.
• W1553913360 hasPublicationYear "1991" @default.
• W1553913360 type Work @default.
• W1553913360 sameAs 1553913360 @default.
• W1553913360 citedByCount "35" @default.
• W1553913360 countsByYear W15539133602013 @default.
• W1553913360 countsByYear W15539133602014 @default.
• W1553913360 countsByYear W15539133602015 @default.
• W1553913360 countsByYear W15539133602017 @default.
• W1553913360 countsByYear W15539133602019 @default.
• W1553913360 countsByYear W15539133602020 @default.
• W1553913360 countsByYear W15539133602021 @default.
• W1553913360 countsByYear W15539133602022 @default.
• W1553913360 countsByYear W15539133602023 @default.
• W1553913360 crossrefType "journal-article" @default.
• W1553913360 hasAuthorship W1553913360A5007333586 @default.
• W1553913360 hasAuthorship W1553913360A5062792890 @default.
• W1553913360 hasAuthorship W1553913360A5078434024 @default.
• W1553913360 hasAuthorship W1553913360A5082820216 @default.
• W1553913360 hasAuthorship W1553913360A5085731615 @default.
• W1553913360 hasBestOaLocation W15539133601 @default.
• W1553913360 hasConcept C170493617 @default.
• W1553913360 hasConcept C185592680 @default.
• W1553913360 hasConcept C202751555 @default.
• W1553913360 hasConcept C2776330855 @default.
• W1553913360 hasConcept C2777132085 @default.
• W1553913360 hasConcept C2778918659 @default.
• W1553913360 hasConcept C2779244956 @default.
• W1553913360 hasConcept C2780726299 @default.
• W1553913360 hasConcept C2780881558 @default.
• W1553913360 hasConcept C41625074 @default.
• W1553913360 hasConcept C46721173 @default.
• W1553913360 hasConcept C55493867 @default.
• W1553913360 hasConcept C8051207 @default.
• W1553913360 hasConceptScore W1553913360C170493617 @default.
• W1553913360 hasConceptScore W1553913360C185592680 @default.
• W1553913360 hasConceptScore W1553913360C202751555 @default.
• W1553913360 hasConceptScore W1553913360C2776330855 @default.
• W1553913360 hasConceptScore W1553913360C2777132085 @default.
• W1553913360 hasConceptScore W1553913360C2778918659 @default.
• W1553913360 hasConceptScore W1553913360C2779244956 @default.

• next