Matches in SemOpenAlex for { <https://semopenalex.org/work/W1553987495> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1553987495 endingPage "1300" @default.
- W1553987495 startingPage "1296" @default.
- W1553987495 abstract "We investigated the mechanisms by which 16,16-dimethyl prostaglandin E2 and histamine induced pancreatic hemorrhage in an experimental model of acute pancreatitis in cats. In normal animals, when large molecular weight dextran molecules were infused into the systematic circulation, they were recovered in secretin-stimulated pancreatic juice in low concentrations. Both 16,16-dimethyl prostaglandin E2 (in a dose that increased splenic artery blood flow and microvascular permeability) and histamine (in a dose that increased permeability only) increased the amount of dextran recovered in pancreatic juice. Isoproterenol, in a dose that produced the same increase in blood flow as 16,16-dimethyl prostaglandin E2 but which did not increase microvascular permeability, did not alter the amount of dextran recovered. This suggested that the increase in dextran output after 16,16-dimethyl prostaglandin E2 was primarily due to the increase in microvascular permeability caused by the drug. In other experiments, a combination of H1- and H2-receptor antagonists (mepyramine and cimetidine) protected against the development of pancreatic hemorrhage in both the prostaglandin- and histamine-treated animals. Indomethacin (a cyclooxygenase inhibitor) protected against the development of hemorrhage in the histamine-treated animals. Our results support the hypothesis that changes in microvascular permeability may be important in the pathogenesis of parenchymal hemorrhage in this model." @default.
- W1553987495 created "2016-06-24" @default.
- W1553987495 creator A5019576697 @default.
- W1553987495 creator A5023588466 @default.
- W1553987495 creator A5053985126 @default.
- W1553987495 date "1987-12-01" @default.
- W1553987495 modified "2023-09-25" @default.
- W1553987495 title "Vasoactive drugs, microvascular permeability, and hemorrhagic pancreatitis in cats" @default.
- W1553987495 cites W1712111403 @default.
- W1553987495 cites W1857027202 @default.
- W1553987495 cites W1965556709 @default.
- W1553987495 cites W1993952427 @default.
- W1553987495 cites W1997050390 @default.
- W1553987495 cites W2001555248 @default.
- W1553987495 cites W2001668786 @default.
- W1553987495 cites W2004987518 @default.
- W1553987495 cites W2022267481 @default.
- W1553987495 cites W2034561959 @default.
- W1553987495 cites W2052031545 @default.
- W1553987495 cites W2058739360 @default.
- W1553987495 cites W2059300226 @default.
- W1553987495 cites W2060278557 @default.
- W1553987495 cites W2068949704 @default.
- W1553987495 cites W2075023881 @default.
- W1553987495 cites W2082176868 @default.
- W1553987495 cites W2083340033 @default.
- W1553987495 cites W2117069717 @default.
- W1553987495 cites W2886869436 @default.
- W1553987495 cites W4320801011 @default.
- W1553987495 doi "https://doi.org/10.1016/0016-5085(87)90258-7" @default.
- W1553987495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3678748" @default.
- W1553987495 hasPublicationYear "1987" @default.
- W1553987495 type Work @default.
- W1553987495 sameAs 1553987495 @default.
- W1553987495 citedByCount "14" @default.
- W1553987495 countsByYear W15539874952012 @default.
- W1553987495 crossrefType "journal-article" @default.
- W1553987495 hasAuthorship W1553987495A5019576697 @default.
- W1553987495 hasAuthorship W1553987495A5023588466 @default.
- W1553987495 hasAuthorship W1553987495A5053985126 @default.
- W1553987495 hasBestOaLocation W15539874951 @default.
- W1553987495 hasConcept C1122143 @default.
- W1553987495 hasConcept C113045295 @default.
- W1553987495 hasConcept C126322002 @default.
- W1553987495 hasConcept C134018914 @default.
- W1553987495 hasConcept C170493617 @default.
- W1553987495 hasConcept C185592680 @default.
- W1553987495 hasConcept C2775967933 @default.
- W1553987495 hasConcept C2776670229 @default.
- W1553987495 hasConcept C2776885963 @default.
- W1553987495 hasConcept C2777339698 @default.
- W1553987495 hasConcept C2777956040 @default.
- W1553987495 hasConcept C2779090179 @default.
- W1553987495 hasConcept C55493867 @default.
- W1553987495 hasConcept C71924100 @default.
- W1553987495 hasConcept C98274493 @default.
- W1553987495 hasConceptScore W1553987495C1122143 @default.
- W1553987495 hasConceptScore W1553987495C113045295 @default.
- W1553987495 hasConceptScore W1553987495C126322002 @default.
- W1553987495 hasConceptScore W1553987495C134018914 @default.
- W1553987495 hasConceptScore W1553987495C170493617 @default.
- W1553987495 hasConceptScore W1553987495C185592680 @default.
- W1553987495 hasConceptScore W1553987495C2775967933 @default.
- W1553987495 hasConceptScore W1553987495C2776670229 @default.
- W1553987495 hasConceptScore W1553987495C2776885963 @default.
- W1553987495 hasConceptScore W1553987495C2777339698 @default.
- W1553987495 hasConceptScore W1553987495C2777956040 @default.
- W1553987495 hasConceptScore W1553987495C2779090179 @default.
- W1553987495 hasConceptScore W1553987495C55493867 @default.
- W1553987495 hasConceptScore W1553987495C71924100 @default.
- W1553987495 hasConceptScore W1553987495C98274493 @default.
- W1553987495 hasIssue "6" @default.
- W1553987495 hasLocation W15539874951 @default.
- W1553987495 hasLocation W15539874952 @default.
- W1553987495 hasOpenAccess W1553987495 @default.
- W1553987495 hasPrimaryLocation W15539874951 @default.
- W1553987495 hasRelatedWork W1965692775 @default.
- W1553987495 hasRelatedWork W1979923131 @default.
- W1553987495 hasRelatedWork W1981043540 @default.
- W1553987495 hasRelatedWork W1983315707 @default.
- W1553987495 hasRelatedWork W1994394184 @default.
- W1553987495 hasRelatedWork W2053843797 @default.
- W1553987495 hasRelatedWork W2056100207 @default.
- W1553987495 hasRelatedWork W2072323299 @default.
- W1553987495 hasRelatedWork W2172131010 @default.
- W1553987495 hasRelatedWork W2748952813 @default.
- W1553987495 hasVolume "93" @default.
- W1553987495 isParatext "false" @default.
- W1553987495 isRetracted "false" @default.
- W1553987495 magId "1553987495" @default.
- W1553987495 workType "article" @default.