FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554059072> ?p ?o ?g. }

• W1554059072 abstract "Platelet-activating factor (l-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine; PAF) enhances the release of newly synthesized PAF as measured by [3H]acetate incorporation into PAF in human neutrophils. The response was dose-dependent, rapid, transient, and inhibitable by the PAF antagonist BN-52021. The non-metabolizahle bioactive PAF analogue (C-PAF) but not lyso-PAF enhances the release of newly synthesized PAF. Newly synthesized PAF was also released after stimulation of these cells with fMet-Leu-Phe. The human granulocyte-macrophage colony-stimulating factor potentiates the stimulated release of PAF. The intracellular calcium chelator BAPTA inhibits the rise of [Ca2+]i and the release of PAF but not the Na+/H+antiport activity. PAF release, but not the rise in the intracellular concentration of free calcium, was inhibited in pertussis toxin-treated neutrophils stimulated with PAF. The release of PAF in pertussis toxin-treated cells was also inhibited in cells stimulated with fMet-Leu-Phe or opsonized zymosan. These results suggest that functional pertussis toxin-sensitive guanine nucleotide regulatory protein and/or one or more of the changes produced by phospholipase C activation are necessary for PAF release produced by physiological stimuli. It appears that PAF release requires a coordinated action of receptor-coupled G-proteins, calcium, and other parameters." @default.
• W1554059072 created "2016-06-24" @default.
• W1554059072 creator A5051291251 @default.
• W1554059072 creator A5057067211 @default.
• W1554059072 creator A5058847020 @default.
• W1554059072 creator A5070665799 @default.
• W1554059072 creator A5081541163 @default.
• W1554059072 date "1989-12-01" @default.
• W1554059072 modified "2023-10-16" @default.
• W1554059072 title "Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli" @default.
• W1554059072 cites W1019611522 @default.
• W1554059072 cites W1489676968 @default.
• W1554059072 cites W1537673842 @default.
• W1554059072 cites W1557110126 @default.
• W1554059072 cites W1893528652 @default.
• W1554059072 cites W1942790970 @default.
• W1554059072 cites W1967612075 @default.
• W1554059072 cites W1978972285 @default.
• W1554059072 cites W1993861621 @default.
• W1554059072 cites W2004088054 @default.
• W1554059072 cites W2015072125 @default.
• W1554059072 cites W2031908250 @default.
• W1554059072 cites W2041743323 @default.
• W1554059072 cites W2051635552 @default.
• W1554059072 cites W2060507826 @default.
• W1554059072 cites W2065376637 @default.
• W1554059072 cites W2113943014 @default.
• W1554059072 cites W2145090129 @default.
• W1554059072 cites W2152311269 @default.
• W1554059072 cites W2337130094 @default.
• W1554059072 cites W2410099630 @default.
• W1554059072 doi "https://doi.org/10.1016/s0021-9258(20)88242-8" @default.
• W1554059072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2513317" @default.
• W1554059072 hasPublicationYear "1989" @default.
• W1554059072 type Work @default.
• W1554059072 sameAs 1554059072 @default.
• W1554059072 citedByCount "27" @default.
• W1554059072 crossrefType "journal-article" @default.
• W1554059072 hasAuthorship W1554059072A5051291251 @default.
• W1554059072 hasAuthorship W1554059072A5057067211 @default.
• W1554059072 hasAuthorship W1554059072A5058847020 @default.
• W1554059072 hasAuthorship W1554059072A5070665799 @default.
• W1554059072 hasAuthorship W1554059072A5081541163 @default.
• W1554059072 hasBestOaLocation W15540590721 @default.
• W1554059072 hasConcept C134018914 @default.
• W1554059072 hasConcept C170493617 @default.
• W1554059072 hasConcept C178790620 @default.
• W1554059072 hasConcept C181080969 @default.
• W1554059072 hasConcept C181199279 @default.
• W1554059072 hasConcept C185592680 @default.
• W1554059072 hasConcept C202751555 @default.
• W1554059072 hasConcept C2776551241 @default.
• W1554059072 hasConcept C2776888444 @default.
• W1554059072 hasConcept C2778870864 @default.
• W1554059072 hasConcept C2779020240 @default.
• W1554059072 hasConcept C49773422 @default.
• W1554059072 hasConcept C519063684 @default.
• W1554059072 hasConcept C55493867 @default.
• W1554059072 hasConcept C79879829 @default.
• W1554059072 hasConcept C80631254 @default.
• W1554059072 hasConcept C86803240 @default.
• W1554059072 hasConcept C99971728 @default.
• W1554059072 hasConceptScore W1554059072C134018914 @default.
• W1554059072 hasConceptScore W1554059072C170493617 @default.
• W1554059072 hasConceptScore W1554059072C178790620 @default.
• W1554059072 hasConceptScore W1554059072C181080969 @default.
• W1554059072 hasConceptScore W1554059072C181199279 @default.
• W1554059072 hasConceptScore W1554059072C185592680 @default.
• W1554059072 hasConceptScore W1554059072C202751555 @default.
• W1554059072 hasConceptScore W1554059072C2776551241 @default.
• W1554059072 hasConceptScore W1554059072C2776888444 @default.
• W1554059072 hasConceptScore W1554059072C2778870864 @default.
• W1554059072 hasConceptScore W1554059072C2779020240 @default.
• W1554059072 hasConceptScore W1554059072C49773422 @default.
• W1554059072 hasConceptScore W1554059072C519063684 @default.
• W1554059072 hasConceptScore W1554059072C55493867 @default.
• W1554059072 hasConceptScore W1554059072C79879829 @default.
• W1554059072 hasConceptScore W1554059072C80631254 @default.
• W1554059072 hasConceptScore W1554059072C86803240 @default.
• W1554059072 hasConceptScore W1554059072C99971728 @default.
• W1554059072 hasLocation W15540590721 @default.
• W1554059072 hasOpenAccess W1554059072 @default.
• W1554059072 hasPrimaryLocation W15540590721 @default.
• W1554059072 hasRelatedWork W1507723867 @default.
• W1554059072 hasRelatedWork W1509625360 @default.
• W1554059072 hasRelatedWork W1643013712 @default.
• W1554059072 hasRelatedWork W1864853899 @default.
• W1554059072 hasRelatedWork W1911256417 @default.
• W1554059072 hasRelatedWork W1954695648 @default.
• W1554059072 hasRelatedWork W1980633655 @default.
• W1554059072 hasRelatedWork W1984436661 @default.
• W1554059072 hasRelatedWork W2040828772 @default.
• W1554059072 hasRelatedWork W2102235686 @default.
• W1554059072 hasRelatedWork W2154657571 @default.
• W1554059072 hasRelatedWork W2160820460 @default.
• W1554059072 hasRelatedWork W2261984195 @default.
• W1554059072 hasRelatedWork W2269348110 @default.
• W1554059072 hasRelatedWork W2338194453 @default.
• W1554059072 hasRelatedWork W2396181027 @default.
• W1554059072 hasRelatedWork W2463672472 @default.

• next