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- W155407629 abstract "Direct viral DNA or RNA detection by genomic amplification methods should contribute to the improvement of blood supply safety by reducing the pre-seroconversion window period. However, nucleic acid testing may not eliminate virus transmission from window period donations. Moreover, the virus subtype diversity has to be taken into account for the choice of nucleic amplification assays. Technology for nucleic acid testing has not been developed to be implemented in blood screening laboratories. The limitations of these procedures are mainly linked to the difficulties related to the automation of sample processing and to the possibilities of cross contamination of samples due to the high sensitivity of amplification methods. The extreme complexity of nucleic acid testing for single donation screening (development of an on-site automated high-throughput instrumentation, training, specialized facilities for sample processing, amplification and detection...) and its high cost mean that strategies using amplification testing of pooled samples should be developed." @default.
- W155407629 created "2016-06-24" @default.
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- W155407629 date "1998-04-01" @default.
- W155407629 modified "2023-10-01" @default.
- W155407629 title "Réflexions concernant le dépistage des acides nucléiques des virus des hépatites B et C et du virus de l'immunodéficience humaine dans la qualification biologique des dons" @default.
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- W155407629 doi "https://doi.org/10.1016/s1246-7820(98)80004-9" @default.
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