FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554082852> ?p ?o ?g. }

• W1554082852 endingPage "1876" @default.
• W1554082852 startingPage "1866" @default.
• W1554082852 abstract "In gonadectomized (GDX) animals replaced with subcutaneous steroid implants supplying physiological levels of testosterone (T; 1-10 ng/ml), the magnitude of adrenocorticotropic hormone (ACTH) and corticosterone (B) responses to restraint was negatively correlated with the level of T replacement, reflecting the inhibitory influence of T on hypothalamic-pituitary-adrenal (HPA) responses to stress. Although T had no effect on resting-state levels of corticotropin-releasing hormone (CRH) in the median eminence, arginine vasopressin (AVP) levels were significantly lower in GDX animals replaced with higher T levels, and the magnitude of the ACTH response to restraint was strongly correlated with median eminence levels of AVP. High physiological levels of T increased glucocorticoid receptor binding in the medial preoptic area (MPOA), with no effect on mineralocorticoid receptor binding or on glucocorticoid receptor binding in other regions. Crystalline T or B implants in the MPOA significantly reduced plasma ACTH and B responses to 10 min of restraint stress compared with cholesterol-implanted controls. Moreover, B or T MPOA implants also decreased resting-state levels of AVP but not CRH in the median eminence, and these effects were correlated with ACTH responses to restraint. Finally, lesioning the MPOA blocked the inhibitory effects of high peripheral T levels on ACTH and B responses to restraint. Thus, variations in the magnitude of HPA responses to stress among males are explained in part by individual differences in circulating T levels, and the MPOA is a critical site for this effect via the inhibition of hypophysial AVP." @default.
• W1554082852 created "2016-06-24" @default.
• W1554082852 creator A5034400760 @default.
• W1554082852 creator A5080238101 @default.
• W1554082852 date "1996-03-01" @default.
• W1554082852 modified "2023-10-17" @default.
• W1554082852 title "The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area" @default.
• W1554082852 cites W1498494065 @default.
• W1554082852 cites W1547358456 @default.
• W1554082852 cites W1587738994 @default.
• W1554082852 cites W1889567471 @default.
• W1554082852 cites W1964015085 @default.
• W1554082852 cites W1967477278 @default.
• W1554082852 cites W1972389227 @default.
• W1554082852 cites W1981480708 @default.
• W1554082852 cites W1985001706 @default.
• W1554082852 cites W1986413865 @default.
• W1554082852 cites W2001357489 @default.
• W1554082852 cites W2005344985 @default.
• W1554082852 cites W2009712356 @default.
• W1554082852 cites W2012630087 @default.
• W1554082852 cites W2014570372 @default.
• W1554082852 cites W2014619876 @default.
• W1554082852 cites W2019044441 @default.
• W1554082852 cites W2019119224 @default.
• W1554082852 cites W2022658269 @default.
• W1554082852 cites W2027002868 @default.
• W1554082852 cites W2027848195 @default.
• W1554082852 cites W2030063067 @default.
• W1554082852 cites W2030108220 @default.
• W1554082852 cites W2030176737 @default.
• W1554082852 cites W2030436882 @default.
• W1554082852 cites W2031558003 @default.
• W1554082852 cites W2035868356 @default.
• W1554082852 cites W2042975266 @default.
• W1554082852 cites W2043034364 @default.
• W1554082852 cites W2044352300 @default.
• W1554082852 cites W2047227717 @default.
• W1554082852 cites W2047723877 @default.
• W1554082852 cites W2049527356 @default.
• W1554082852 cites W2050108249 @default.
• W1554082852 cites W2050581082 @default.
• W1554082852 cites W2053350953 @default.
• W1554082852 cites W2053414344 @default.
• W1554082852 cites W2054143056 @default.
• W1554082852 cites W2061507738 @default.
• W1554082852 cites W2061514092 @default.
• W1554082852 cites W2072650176 @default.
• W1554082852 cites W2073750567 @default.
• W1554082852 cites W2074573463 @default.
• W1554082852 cites W2077232584 @default.
• W1554082852 cites W2078288264 @default.
• W1554082852 cites W2080256190 @default.
• W1554082852 cites W2082041220 @default.
• W1554082852 cites W2088133721 @default.
• W1554082852 cites W2128635872 @default.
• W1554082852 cites W2140288223 @default.
• W1554082852 cites W2148439332 @default.
• W1554082852 cites W2149315188 @default.
• W1554082852 cites W2156147980 @default.
• W1554082852 cites W2163815564 @default.
• W1554082852 cites W2170146128 @default.
• W1554082852 cites W2172640261 @default.
• W1554082852 cites W2418847833 @default.
• W1554082852 cites W2896221891 @default.
• W1554082852 doi "https://doi.org/10.1523/jneurosci.16-05-01866.1996" @default.
• W1554082852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6578699" @default.
• W1554082852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8774455" @default.
• W1554082852 hasPublicationYear "1996" @default.
• W1554082852 type Work @default.
• W1554082852 sameAs 1554082852 @default.
• W1554082852 citedByCount "315" @default.
• W1554082852 countsByYear W15540828522012 @default.
• W1554082852 countsByYear W15540828522013 @default.
• W1554082852 countsByYear W15540828522014 @default.
• W1554082852 countsByYear W15540828522015 @default.
• W1554082852 countsByYear W15540828522016 @default.
• W1554082852 countsByYear W15540828522017 @default.
• W1554082852 countsByYear W15540828522018 @default.
• W1554082852 countsByYear W15540828522019 @default.
• W1554082852 countsByYear W15540828522020 @default.
• W1554082852 countsByYear W15540828522021 @default.
• W1554082852 countsByYear W15540828522022 @default.
• W1554082852 countsByYear W15540828522023 @default.
• W1554082852 crossrefType "journal-article" @default.
• W1554082852 hasAuthorship W1554082852A5034400760 @default.
• W1554082852 hasAuthorship W1554082852A5080238101 @default.
• W1554082852 hasBestOaLocation W15540828521 @default.
• W1554082852 hasConcept C126322002 @default.
• W1554082852 hasConcept C134018914 @default.
• W1554082852 hasConcept C17077164 @default.
• W1554082852 hasConcept C185592680 @default.
• W1554082852 hasConcept C2776370428 @default.
• W1554082852 hasConcept C2777003273 @default.
• W1554082852 hasConcept C2778458438 @default.
• W1554082852 hasConcept C2779067335 @default.
• W1554082852 hasConcept C2779279991 @default.
• W1554082852 hasConcept C2780352252 @default.

• next