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- W1554093482 abstract "Adhesion and motility of cells on polyethylene glycol (PEG) engineered surfaces are of fundamental interest for the development of biotechnological devices. Here, the structure of PEG block copolymers physisorbed to surfaces by polyLlysine (PLL) or polypropylene oxide (PPO) is studied. Cell behavior on such surfaces incubated with fibronectin (FN) is analyzed via time-lapse microscopy, the amount and the location of FN is determined via neutron reflectivity. While FN does not adsorb onto PPOPEG, 0.4-0.7 mg m(-2) of FN is found in the vicinity of the PLL moiety of PLLPEG. Cells exhibit 21% increased motility on PLLPEG (5 kDa PEG chains) compared to pure FN layers, and 12% decreased motility for PLLPEG (2 kDa PEG chains). These findings suggest that by design of PEGylated surfaces cell migration can be controlled." @default.
- W1554093482 created "2016-06-24" @default.
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- W1554093482 date "2014-09-10" @default.
- W1554093482 modified "2023-10-02" @default.
- W1554093482 title "Cell Motility on Polyethylene Glycol Block Copolymers Correlates to Fibronectin Surface Adsorption" @default.
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- W1554093482 doi "https://doi.org/10.1002/mabi.201400246" @default.
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