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- W1554161031 abstract "A simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma has been used widely for in vitro assessment of the bioactivity of artificial materials. A conventional SBF (c-SBF) in general use, however, has lower HCO 3 - and higher Cl - ion concentrations than those of human blood plasma. It is known that a performance of c-SBF does not always show good reproducibility, partially due to the preparing process of SBF. In the present study, the preparation process was modified, and a newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO 3 - , the concentration of which is lower than the level of saturation with respect to calcite. Two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration were prepared and the ion concentrations of prepared n-SBFs were unchanged at least 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs are considered to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material." @default.
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- W1554161031 date "2008-03-26" @default.
- W1554161031 modified "2023-09-24" @default.
- W1554161031 title "New and Conventional Simulated Body Fluids" @default.
- W1554161031 doi "https://doi.org/10.1002/9780470291191.ch86" @default.
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