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- W1554222015 abstract "Abstract Knowledge of dose at the target site is a fundamental starting point In making interspecies dosimetric comparisons. To the extent that information is available on the effective dose of a compound, our confidence in risk assessments Is increased. To facilitate judgments about effects determined in animals relative to likelihood of risk associated with human exposure to ozone (O3), a mathematical dosimetry model has been developed for interspecies comparisons. The model incorporates the major factors affecting the absorption of O3 in the respiratory tract: the morphology of the respiratory tract, the route, depth and rate of breathing, physlcochemlcal properties of O3, the physical and chemical processes which govern gas transport, and the physlcochemical properties of the lining fluids and tissue material of the airways and gas exchange units. This model Is used to identify Issues critically important to the modeling process Itself, such as model validation and modeling uptake of O3 in the head. Also discussed are the application of the dosimetry model for examining age-dependent susceptibility to O3 and the potential usefulness of such models for relating mlcrodoslmetry to mlcrotoxlcology." @default.
- W1554222015 created "2016-06-24" @default.
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- W1554222015 date "1989-01-01" @default.
- W1554222015 modified "2023-09-26" @default.
- W1554222015 title "Critical Issues in Intra- and Interspecies Dosimetry of Ozone" @default.
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- W1554222015 doi "https://doi.org/10.1016/s0166-1116(08)70596-x" @default.
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