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- W1554310999 endingPage "3274" @default.
- W1554310999 startingPage "3266" @default.
- W1554310999 abstract "Human NK cells are likely to be important effectors of xenograft rejection. Expression of HLA class I molecules by transfected porcine cells can protect them from human NK cell-mediated lysis; however, this strategy has the potential to augment the anti-graft response by recipient CD8(+) T cells recognizing foreign pig peptides presented by HLA. In this study we show that the introduction of a mutation (D227K) in the alpha(3) domain of HLA-Cw3 abrogates its recognition by CD8-dependent T cells but leaves intact its ability to function as an inhibitory ligand for NK cells. Such genetically modified molecules may have potential therapeutic applications in the prevention of delayed xenograft rejection and in the facilitation of allogeneic and xenogeneic bone marrow engraftment." @default.
- W1554310999 created "2016-06-24" @default.
- W1554310999 creator A5002051410 @default.
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- W1554310999 creator A5046938956 @default.
- W1554310999 creator A5047520001 @default.
- W1554310999 creator A5057357649 @default.
- W1554310999 date "2002-04-01" @default.
- W1554310999 modified "2023-09-24" @default.
- W1554310999 title "Genetically Modified HLA Class I Molecules Able to Inhibit Human NK Cells Without Provoking Alloreactive CD8+ CTLs" @default.
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