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- W1554325794 abstract "The immunomodulatory effect of Codonopsis lanceolata based on the production of cytokines and the activation of macrophage was studied. The mRNA expression of nitric oxide synthase (iNOS) was gradually induced after 24 hr treatment of Codonopsis lanceolata, and NO production was a maximum after 24 hr treatment with 1 mg/ mL. RAW 264.7 cell on in vitro treatment with Codonopsis lanceolata induced mRNA of cytokines such as interleukin-1(IL-1)β, interleukin-6(IL-6), tumor necrosis factor(TNF)-α and interferon(IFN)-γ; IL-1β and IL-6 mRNA were gradually induced up to 24 hr. TNF-α mRNA was regularly induced up to 24 hr, and IFN-γ mRNA level was a maximum within 1 hr. These results suggest that Codonopsis lanceolata exerts as an effective immunomodulator and enhances antitumor activity of macrophages." @default.
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- W1554325794 date "2004-12-01" @default.
- W1554325794 modified "2023-09-24" @default.
- W1554325794 title "Induction of Nitric Oxide and Cytokines in Macrophages by Codonopsis lanceolata" @default.
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