Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554406962> ?p ?o ?g. }
- W1554406962 abstract "A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis. A20 is frequently inactivated by deletions and/or mutations in several B and T cell lymphoma subtypes; however, knowledge of the role of A20 in B-cell acute lymphoblastic leukemia (B-ALL) remains limited. In this study, we characterized the A20 gene expression pattern, the expression level of its upstream regulating factor MALT1, and its downstream target NF-κB in adult B-ALL.The expression level of MALT1, A20 and NF-κB1 was detected in peripheral blood mononuclear cells (PBMCs) from 20 patients with adult B-ALL (including 12 de novo B-ALL and 8 refractory/relapse B-ALL cases), and nine patients with B-ALL in complete remission (CR) using real-time PCR. Sixteen healthy individuals served as controls.Significant A20 overexpression was found in the B-ALL (median: 13.489) compared with B-ALL CR (median: 3.755) (P = 0.003) patients and healthy individuals (median: 8.748) (P = 0.002), while there was no significant difference in A20 expression between B-ALL CR patients and healthy individuals (P = 0.107). Interestingly, the A20 expression level in the B-ALL samples was relatively different with approximately 50% of the B-ALL cases showing a relatively high A20 expression level, while the remaining 50% cases demonstrated slight upregulation or a similar expression level as the healthy controls. However, there was no significant difference in the A20 expression level between de novo B-ALL (median 12.252) and refractory/relapse B-ALL patients (median 21.342) (P = 0.616). Similarly, a significantly higher expression level of NF-κB1 was found in the B-ALL (median 1.062) patients compared with healthy individuals (median 0.335) (P < 0.0001), while the NF-κB1 expression level was downregulated in the B-ALL CR group (median 0.339), which was significantly lower than that in those with B-ALL (P = 0.001). Moreover, the MALT1 expression level in B-ALL was upregulated (median 1.938) and significantly higher than that in healthy individuals (median 0.677) (P = 0.002) and B-ALL CR patients (median 0.153) (P = 0.008). The correlation of the expression levels of all three genes was lost in B-ALL.We found that MALT1-A20-NF-κB is overexpressed in adult B-ALL, which may be related to the pathogenesis of B-ALL, and this pathway may be considered a potentially attractive target for the development of B-ALL therapeutics." @default.
- W1554406962 created "2016-06-24" @default.
- W1554406962 creator A5000828146 @default.
- W1554406962 creator A5003447311 @default.
- W1554406962 creator A5007159963 @default.
- W1554406962 creator A5012119333 @default.
- W1554406962 creator A5029927299 @default.
- W1554406962 creator A5038134289 @default.
- W1554406962 creator A5056101043 @default.
- W1554406962 creator A5064496142 @default.
- W1554406962 creator A5064710618 @default.
- W1554406962 creator A5064726724 @default.
- W1554406962 creator A5071414306 @default.
- W1554406962 creator A5077001548 @default.
- W1554406962 date "2015-07-25" @default.
- W1554406962 modified "2023-09-26" @default.
- W1554406962 title "Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia" @default.
- W1554406962 cites W102212382 @default.
- W1554406962 cites W1521689717 @default.
- W1554406962 cites W1554981631 @default.
- W1554406962 cites W1574879240 @default.
- W1554406962 cites W1596801838 @default.
- W1554406962 cites W1599671889 @default.
- W1554406962 cites W1963554305 @default.
- W1554406962 cites W1976590012 @default.
- W1554406962 cites W1977303037 @default.
- W1554406962 cites W1977482082 @default.
- W1554406962 cites W1978028015 @default.
- W1554406962 cites W1990045094 @default.
- W1554406962 cites W2006909007 @default.
- W1554406962 cites W2020781390 @default.
- W1554406962 cites W2021662182 @default.
- W1554406962 cites W2023032337 @default.
- W1554406962 cites W2037106665 @default.
- W1554406962 cites W2041670046 @default.
- W1554406962 cites W2046131175 @default.
- W1554406962 cites W2057602257 @default.
- W1554406962 cites W2066054263 @default.
- W1554406962 cites W2067471975 @default.
- W1554406962 cites W2073511730 @default.
- W1554406962 cites W2074165534 @default.
- W1554406962 cites W2085236616 @default.
- W1554406962 cites W2091012188 @default.
- W1554406962 cites W2097400599 @default.
- W1554406962 cites W2107583316 @default.
- W1554406962 cites W2113713863 @default.
- W1554406962 cites W2118083075 @default.
- W1554406962 cites W2121828824 @default.
- W1554406962 cites W2132605816 @default.
- W1554406962 cites W2132991384 @default.
- W1554406962 cites W2135298194 @default.
- W1554406962 cites W2139227377 @default.
- W1554406962 cites W2141773149 @default.
- W1554406962 cites W2145743086 @default.
- W1554406962 cites W2146982263 @default.
- W1554406962 cites W2149835039 @default.
- W1554406962 cites W2160087354 @default.
- W1554406962 cites W2166883361 @default.
- W1554406962 cites W2170789672 @default.
- W1554406962 cites W2374155731 @default.
- W1554406962 doi "https://doi.org/10.1186/s12935-015-0222-0" @default.
- W1554406962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4514975" @default.
- W1554406962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213496" @default.
- W1554406962 hasPublicationYear "2015" @default.
- W1554406962 type Work @default.
- W1554406962 sameAs 1554406962 @default.
- W1554406962 citedByCount "9" @default.
- W1554406962 countsByYear W15544069622017 @default.
- W1554406962 countsByYear W15544069622019 @default.
- W1554406962 countsByYear W15544069622020 @default.
- W1554406962 countsByYear W15544069622021 @default.
- W1554406962 countsByYear W15544069622022 @default.
- W1554406962 crossrefType "journal-article" @default.
- W1554406962 hasAuthorship W1554406962A5000828146 @default.
- W1554406962 hasAuthorship W1554406962A5003447311 @default.
- W1554406962 hasAuthorship W1554406962A5007159963 @default.
- W1554406962 hasAuthorship W1554406962A5012119333 @default.
- W1554406962 hasAuthorship W1554406962A5029927299 @default.
- W1554406962 hasAuthorship W1554406962A5038134289 @default.
- W1554406962 hasAuthorship W1554406962A5056101043 @default.
- W1554406962 hasAuthorship W1554406962A5064496142 @default.
- W1554406962 hasAuthorship W1554406962A5064710618 @default.
- W1554406962 hasAuthorship W1554406962A5064726724 @default.
- W1554406962 hasAuthorship W1554406962A5071414306 @default.
- W1554406962 hasAuthorship W1554406962A5077001548 @default.
- W1554406962 hasBestOaLocation W15544069621 @default.
- W1554406962 hasConcept C104317684 @default.
- W1554406962 hasConcept C121608353 @default.
- W1554406962 hasConcept C126322002 @default.
- W1554406962 hasConcept C127561419 @default.
- W1554406962 hasConcept C137061746 @default.
- W1554406962 hasConcept C159654299 @default.
- W1554406962 hasConcept C170493617 @default.
- W1554406962 hasConcept C17991360 @default.
- W1554406962 hasConcept C190283241 @default.
- W1554406962 hasConcept C202751555 @default.
- W1554406962 hasConcept C203014093 @default.
- W1554406962 hasConcept C2776914184 @default.
- W1554406962 hasConcept C2777730290 @default.
- W1554406962 hasConcept C2777785397 @default.