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- W1554440470 abstract "Publisher Summary The chapter describes the multimeric human IL-2 receptor. With many CD4 T lymphocytes, this ligand-receptor interplay triggers an intracellular signaling cascade leading to the production of the T cell growth factor, interleukin-2 (IL-2), and the concomitant display of functional high affinity membrane receptors for IL-2. IL-2 binding to these high affinity IL-2 receptors generates a second series of intracellular signals culminating in T cell division and clonal expansion of the antigen-reactive cell population. Subsequent decline in IL-2 receptor display and diminished production of IL-2 combine to terminate the T cell immune response. Each of these receptor chains serves a distinct role in the assembly and function of the high affinity IL-2 receptor complex. Salient features of each of the known receptor subunits are discussed. Other studies have shown that the proliferation of these cells can be inhibited by the addition of anti-IL-2 or anti-IL-2 receptor antibodies mediated through an autocrine or paracrine mechanism involving IL-2 and its receptor. In this regard, the TSP/HAM findings mimic the early polyclonal proliferative phase of HTLV-I transformation observed in tissue culture." @default.
- W1554440470 created "2016-06-24" @default.
- W1554440470 creator A5021689661 @default.
- W1554440470 creator A5075675860 @default.
- W1554440470 date "1997-01-01" @default.
- W1554440470 modified "2023-09-24" @default.
- W1554440470 title "The interleukin-2 receptor" @default.
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