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- W1554480355 abstract "Theophylline increases the synthesis of proinsulin and, to a lesser extent, that of non insulinic peptides in isolated islets of Langerhans. Similar to its stimulant action on 45Ca2+ uptake by insular tissue, the preferential stimulant action of theophylline on proinsulin biosynthesis is most marked at low glucose concentration (4.2 mM). It apparently represents a Ca2+-independent process. Since theophylline does not augment glucose uptake by the isolated islets, the glucose-like enhancing action of theophylline on both 45Ca2+ uptake and proinsulin synthesis could be due, in part at least, to a cyclic AMP-mediated stimulation of glycogenolysis." @default.
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- W1554480355 date "1974-08-01" @default.
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- W1554480355 title "The stimulus-secretion coupling of glucose-induced insulin release" @default.
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- W1554480355 doi "https://doi.org/10.1016/0304-4165(74)90033-6" @default.
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