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• W1554550337 abstract "Publisher Summary The chapter presents the nature, occurrence, and significance of the first specific marker chromosome discovered by means of chromosome banding technique: the 14q+ marker—a chromosome 14 with additional material at the end of the long arm. The 14q+ marker remains one of the most significant and interesting chromosomal findings in human tumor cytogenetics, but also perhaps the one most puzzling and perplexing. The chapter also presents a survey of chromosome aberrations identified with banding techniques in 1871 cases of premalignant and malignant disorders. The improved resolution that can be achieved with the use of chromosome banding techniques has made a great impact on the field of cancer genetics, especially on the search for specific and consistent changes. The incidence and type of origin of the different 14q+ marker chromosomes recorded have been described separately for each tumor type; they are: lymphoproliferatidvies orders, myeloproliferative disorder(MD), and solid tumors. The chapter concludes that the characteristic 14q+ marker, produced by the 8; 14 translocation, is a specific marker for B-cell lymphoproliferative disorders. This conclusion is supported by the following observations: the marker has been found only in Burkitt's Lymphoma (BL), Acute Lymphocytic Leukemia (ALL), Malignant Lymphoma (ML) and Chronic Lymphocytic Leukemia (CLL), all cases analyzed for cell surface markers are of B cell type, the marker has not been found in any T or null cell type of leukemia/lymphoma." @default.
• W1554550337 created "2016-06-24" @default.
• W1554550337 creator A5038509696 @default.
• W1554550337 date "1981-01-01" @default.
• W1554550337 modified "2023-10-16" @default.
• W1554550337 title "Transformation by Polyoma Virus and Simian Virus 40" @default.
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• W1554550337 doi "https://doi.org/10.1016/s0065-230x(08)60241-9" @default.
• W1554550337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4343130" @default.
• W1554550337 hasPublicationYear "1981" @default.
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