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• W155459757 abstract "The rab3A gene product is a 25 kDa guanine-nucleotide-binding protein which is expressed at high levels in neural tissue and has about 30% sequence similarity to ras. Purified p25rab3A has been used as substrate to examine its kinetics of nucleotide binding and hydrolysis, and to study the effects of Mg2+ on these processes. p25rab3A binds GDP and GTP similarly well, with nanomolar affinity. Mg2+ increases the affinity between p25rab3A and guanine nucleotides by 3- and 7-fold for GTP and GDP respectively, primarily by drastically decreasing the nucleotide off-rates. The Mg2+ binding affinity to p25rab3A. [alpha 32P]GDP was determined to be about 4 microns using entrapment of [alpha-32P]GDP as a measure of Mg2+ binding. At a Mg2+ concentration of 11 mM. GTPase activity was rate-limited by the GDP off-rate. Surprisingly, at a Mg2+ concentration of 80 nM. GTPase activity was comparable with that in the presence of excess Mg2+. In this case, kcat. was rate-limiting. At Mg2+ concentrations below 10 nM there was no detectable GTPase activity, indicating that Mg2+ is required for the GTPase activity of p25rab3A." @default.
• W155459757 created "2016-06-24" @default.
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• W155459757 date "1992-03-01" @default.
• W155459757 modified "2023-10-17" @default.
• W155459757 title "Interactions of the ras-like protein p25<i>rab 3A</i> with Mg2+ and guanine nucleotides" @default.
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• W155459757 doi "https://doi.org/10.1042/bj2820387" @default.
• W155459757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1130790" @default.
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