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• W155463170 abstract "The involvement of a carrier for sinefungin (SF) uptake in Leishmania donovani promastigotes is indicated by saturation kinetics, competition studies and SF accumulation against a 270-fold concentration gradient across the cell membrane. Whether SF uptake occurs via nucleoside- or AdoMet-carrier systems was investigated by competition experiments and comparison of the uptake of various molecules in wild-type and SF-resistant cells. Results show that SF did not inhibit purine or pyrimidine uptake whereas it competitively inhibited AdoMet uptake. Furthermore, the uptake of nucleosides in SF-resistant cells is similar to that in wild-type cells, whereas uptake of SF and AdoMet is lower." @default.
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• W155463170 date "1995-01-01" @default.
• W155463170 modified "2023-10-18" @default.
• W155463170 title "Sinefungin shares AdoMet-uptake system to enter <i>Leishmania donovani</i> promastigotes" @default.
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• W155463170 doi "https://doi.org/10.1042/bj3050133" @default.
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