FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1554749894> ?p ?o ?g. }

• W1554749894 endingPage "189" @default.
• W1554749894 startingPage "173" @default.
• W1554749894 abstract "Heme‐based sensors are a recently discovered functional class of heme proteins that serve to detect physiological fluctuations in oxygen (O2), carbon monoxide (CO), or nitric oxide (NO). Many of these modular sensors detect heme ligands by coupling a histidine‐protein kinase to a heme‐binding domain. They typically bind O2, CO, and NO but respond only to one of these ligands. Usually, they are active in the ferrous unliganded state but are switched off by saturation with O2. The heme‐binding domains of these kinases are quite varied. They may feature a PAS fold, as in the Bradyrhizobium japonicum and Sinorhizobium melitoti FixL proteins, or a GAF fold, as in the Mycobacterium tuberculosis DevS and DosT proteins. Alternative folds, such as HNOB (also H‐NOX), have also been noted for such signal‐transducing kinases, although these classes are less well studied. Histidine‐protein kinases function in partnership with cognate response‐regulator substrate(s): usually transcription factors that they activate by phosphorylation. For example, FixL proteins specifically phosphorylate their FixJ partners, and DevS and DosT proteins phosphorylate DevR in response to hypoxia. We present methods for purifying these sensors and their protein substrates, verifying the quality of the preparations, determining the Kd values for binding of ligand and preparing sensors of known saturation, and measuring the rates of turnover (kcat) of the protein substrate by sensors of known heme status." @default.
• W1554749894 created "2016-06-24" @default.
• W1554749894 creator A5007841788 @default.
• W1554749894 creator A5049228329 @default.
• W1554749894 creator A5050613763 @default.
• W1554749894 creator A5067103970 @default.
• W1554749894 date "2008-01-01" @default.
• W1554749894 modified "2023-09-27" @default.
• W1554749894 title "Oxygen‐Sensing Histidine‐Protein Kinases: Assays of Ligand Binding and Turnover of Response‐Regulator Substrates" @default.
• W1554749894 cites W1023310599 @default.
• W1554749894 cites W1510941613 @default.
• W1554749894 cites W1519638961 @default.
• W1554749894 cites W1568194448 @default.
• W1554749894 cites W1589203341 @default.
• W1554749894 cites W1614520810 @default.
• W1554749894 cites W1789605787 @default.
• W1554749894 cites W1855786738 @default.
• W1554749894 cites W1897119888 @default.
• W1554749894 cites W1978687530 @default.
• W1554749894 cites W1983838393 @default.
• W1554749894 cites W1988318747 @default.
• W1554749894 cites W1999278302 @default.
• W1554749894 cites W2005483187 @default.
• W1554749894 cites W2007136514 @default.
• W1554749894 cites W2007998884 @default.
• W1554749894 cites W2018778544 @default.
• W1554749894 cites W2032566862 @default.
• W1554749894 cites W2035562855 @default.
• W1554749894 cites W2044816439 @default.
• W1554749894 cites W2045758984 @default.
• W1554749894 cites W2053292205 @default.
• W1554749894 cites W2053609853 @default.
• W1554749894 cites W2054819068 @default.
• W1554749894 cites W2055101875 @default.
• W1554749894 cites W2056138404 @default.
• W1554749894 cites W2063748385 @default.
• W1554749894 cites W2077485583 @default.
• W1554749894 cites W2080194254 @default.
• W1554749894 cites W2080354196 @default.
• W1554749894 cites W2082089547 @default.
• W1554749894 cites W2083087021 @default.
• W1554749894 cites W2086037622 @default.
• W1554749894 cites W2089337124 @default.
• W1554749894 cites W2100837269 @default.
• W1554749894 cites W2114513616 @default.
• W1554749894 cites W2116304162 @default.
• W1554749894 cites W2122023734 @default.
• W1554749894 cites W2135304977 @default.
• W1554749894 cites W2145072890 @default.
• W1554749894 cites W2148665382 @default.
• W1554749894 cites W2163720557 @default.
• W1554749894 cites W4245067683 @default.
• W1554749894 doi "https://doi.org/10.1016/s0076-6879(07)37010-9" @default.
• W1554749894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18433629" @default.
• W1554749894 hasPublicationYear "2008" @default.
• W1554749894 type Work @default.
• W1554749894 sameAs 1554749894 @default.
• W1554749894 citedByCount "21" @default.
• W1554749894 countsByYear W15547498942013 @default.
• W1554749894 countsByYear W15547498942016 @default.
• W1554749894 countsByYear W15547498942017 @default.
• W1554749894 countsByYear W15547498942019 @default.
• W1554749894 countsByYear W15547498942020 @default.
• W1554749894 countsByYear W15547498942021 @default.
• W1554749894 countsByYear W15547498942022 @default.
• W1554749894 crossrefType "book-chapter" @default.
• W1554749894 hasAuthorship W1554749894A5007841788 @default.
• W1554749894 hasAuthorship W1554749894A5049228329 @default.
• W1554749894 hasAuthorship W1554749894A5050613763 @default.
• W1554749894 hasAuthorship W1554749894A5067103970 @default.
• W1554749894 hasConcept C104317684 @default.
• W1554749894 hasConcept C11960822 @default.
• W1554749894 hasConcept C143065580 @default.
• W1554749894 hasConcept C181199279 @default.
• W1554749894 hasConcept C184235292 @default.
• W1554749894 hasConcept C185592680 @default.
• W1554749894 hasConcept C2776217839 @default.
• W1554749894 hasConcept C2778460671 @default.
• W1554749894 hasConcept C2778875234 @default.
• W1554749894 hasConcept C2778905257 @default.
• W1554749894 hasConcept C2779856404 @default.
• W1554749894 hasConcept C2781196521 @default.
• W1554749894 hasConcept C2781385570 @default.
• W1554749894 hasConcept C43144210 @default.
• W1554749894 hasConcept C523546767 @default.
• W1554749894 hasConcept C54355233 @default.
• W1554749894 hasConcept C55493867 @default.
• W1554749894 hasConcept C86339819 @default.
• W1554749894 hasConcept C86803240 @default.
• W1554749894 hasConcept C95444343 @default.
• W1554749894 hasConceptScore W1554749894C104317684 @default.
• W1554749894 hasConceptScore W1554749894C11960822 @default.
• W1554749894 hasConceptScore W1554749894C143065580 @default.
• W1554749894 hasConceptScore W1554749894C181199279 @default.
• W1554749894 hasConceptScore W1554749894C184235292 @default.
• W1554749894 hasConceptScore W1554749894C185592680 @default.
• W1554749894 hasConceptScore W1554749894C2776217839 @default.
• W1554749894 hasConceptScore W1554749894C2778460671 @default.

• next