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• W1554784279 abstract "Abstract Although natural Abs (NAbs) are present from birth, little is known about what drives their selection and whether they have housekeeping functions. The prototypic T15-NAb, first identified because of its protective role in infection, is representative of a special type of NAb response that specifically recognizes and forms complexes with apoptotic cells and which promotes cell-corpse engulfment by phagocytes. We now show that this T15-NAb IgM-mediated clearance process is dependent on the recruitment of C1q and mannose-binding lectin, which have known immune modulatory activities that also provide “eat me” signals for enhancing phagocytosis. Further investigation revealed that the addition of T15-NAb significantly suppressed in vitro LPS-induced TNF-α and IL-6 secretion by the macrophage-like cell line, RAW264.7, as well as TLR3-, TLR4-, TLR7-, and TLR9-induced maturation and secretion of a range of proinflammatory cytokines and chemokines by bone marrow-derived conventional dendritic cells. Significantly, high doses of this B-1 cell produced NAb also suppressed in vivo TLR-induced proinflammatory responses. Although infusions of apoptotic cells also suppressed such in vivo inflammatory responses and this effect was associated with the induction of high levels of IgM antiapoptotic cell Abs, apoptotic cell treatment was not effective at suppressing such TLR responses in B cell-deficient mice. Moreover, infusions of T15-NAb also efficiently inhibited both collagen-induced arthritis and anti-collagen II Ab-mediated arthritis. These studies identify and characterize a previously unknown regulatory circuit by which a NAb product of innate-like B cells aids homeostasis by control of fundamental inflammatory pathways." @default.
• W1554784279 created "2016-06-24" @default.
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• W1554784279 date "2009-07-15" @default.
• W1554784279 modified "2023-09-25" @default.
• W1554784279 title "Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis" @default.
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• W1554784279 cites W1561583071 @default.
• W1554784279 cites W1573250191 @default.
• W1554784279 cites W1630503232 @default.
• W1554784279 cites W1677439338 @default.
• W1554784279 cites W1837942605 @default.
• W1554784279 cites W1873874031 @default.
• W1554784279 cites W1929879919 @default.
• W1554784279 cites W1942720838 @default.
• W1554784279 cites W1969373801 @default.
• W1554784279 cites W1972715229 @default.
• W1554784279 cites W1974489930 @default.
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• W1554784279 cites W1978025330 @default.
• W1554784279 cites W1980082178 @default.
• W1554784279 cites W1985477675 @default.
• W1554784279 cites W1988536357 @default.
• W1554784279 cites W1994611646 @default.
• W1554784279 cites W1999765902 @default.
• W1554784279 cites W2000574489 @default.
• W1554784279 cites W2003701673 @default.
• W1554784279 cites W2007765422 @default.
• W1554784279 cites W2012601418 @default.
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• W1554784279 cites W2035319097 @default.
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• W1554784279 cites W2048086309 @default.
• W1554784279 cites W2050043073 @default.
• W1554784279 cites W2050579891 @default.
• W1554784279 cites W2051151466 @default.
• W1554784279 cites W2052494323 @default.
• W1554784279 cites W2053180426 @default.
• W1554784279 cites W2053782526 @default.
• W1554784279 cites W2054488343 @default.
• W1554784279 cites W2057064377 @default.
• W1554784279 cites W2065170172 @default.
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• W1554784279 cites W2113554363 @default.
• W1554784279 cites W2116592902 @default.
• W1554784279 cites W2118362622 @default.
• W1554784279 cites W2123180572 @default.
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• W1554784279 doi "https://doi.org/10.4049/jimmunol.0900948" @default.
• W1554784279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713016" @default.
• W1554784279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19564341" @default.
• W1554784279 hasPublicationYear "2009" @default.
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